TY - JOUR AU - Para, Ombretta AU - Crispino, Pietro AU - Barone, Nunzia AU - Macis, Sara AU - Airasca, Laura AU - Gnerre, Paola AU - Politi, Cecilia PY - 2018/03/20 Y2 - 2024/03/28 TI - Sex differences in adverse drug reaction and liver disease JF - Italian Journal of Medicine JA - Ital J Med VL - 12 IS - 1 SE - Reviews DO - 10.4081/itjm.2018.893 UR - https://www.italjmed.org/ijm/article/view/itjm.2018.893 SP - 15-22 AB - Adverse drug reactions represent a significant public health problem. A share of no small adverse reaction is particularly serious and can even lead to patient's death. Furthermore, hepatitis induced by serious drug reactions is a rare event but potentially fatal. Finally, we know that epidemiological studies have highlighted male gender as an independent predictor of fibrosis progression towards cirrhosis in hepatitis B and C-virus, as well as non-alcoholic steatohepatitis. The importance of considering the differences between the male and female sex in clinical decision-making is crucial. The physiopathology of liver disease is different in the two genres, but these differences are not yet fully known and several potential mechanisms have been identified. ER -