TY - JOUR AU - Alletto, Maurizio AU - Burgio, Antonio AU - Fulco, Giovanni AU - Geraci, Giulio AU - Groppuso, Concetta AU - Gruttadauria, Gianfranco AU - Manfrè, Elvio AU - Mastrosimone, Gianluca AU - Salvaggio, Susanna AU - Urrico, Giovanni AU - Vancheri, Federico PY - 2020/05/19 Y2 - 2024/03/29 TI - Severe paraneoplastic hypoglycemia due to a non-islet cell tumor in a patient with an advanced gastrointestinal stromal tumor JF - Italian Journal of Medicine JA - Ital J Med VL - 14 IS - 3 SE - Case Reports DO - 10.4081/itjm.2020.1276 UR - https://www.italjmed.org/ijm/article/view/itjm.2020.1276 SP - 167-171 AB - <p>Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, mainly localized in the stomach. Most GISTs derive from mutations in tyrosine kinase receptors or platelet-derived growth factor receptor-α. GISTs are rarely associated with paraneoplastic hypoglycemia caused by a non-β-cells tumor. This syndrome, defined non-islet cell tumor hypoglycemia (NICTH), arises from excess tumor production of insulin-like growth factor. We describe the case of a 67-year-old female with severe NICTH secondary to an advanced and metastatic GIST.</p> ER -