The challenging diagnosis of intravascular large B-cell lymphoma

Abstract

Livedo reticularis (LR) is a net-like cyanotic skin pattern resulting from cutaneous blood flow disturbance associated with several medical conditions. The authors present a case of a 77-year-old woman with a history of asthenia over one year, admitted to the hospital with sepsis by pneumonia. During her hospitalization, she developed a livedoid rash, and skin biopsy revealed infiltrates of atypical mononuclear cells causing capillary lumen obstruction. Intravascular large B-cell lymphoma was suspected and confirmed by bone marrow study. This case highlights the importance of being aware of different medical conditions associated with LR and the atypical presentation of a lymphoproliferative disorder.

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References

Dean MS. Livedo reticularis and related disorders. Curr Treat Options Cardiovasc Med 2011;13:179-91. DOI: https://doi.org/10.1007/s11936-011-0115-z

Röglin J, Böer A. Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin. Br J Dermatol 2007;157:16-25. DOI: https://doi.org/10.1111/j.1365-2133.2007.07954.x

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Ong YC, Kao HW, Chuang WY, et al. Intravascular large B-cell lymphoma: a case series and review of literatures. Biomed J 2020;S2319-4170(20)30041-X. DOI: https://doi.org/10.1016/j.bj.2020.04.005

Charifa A, Paulson N, Levy L, et al. Intravascular large B-Cell lymphoma: clinical and histopathologic findings. Yale J Biol Med 2020;93:35‐40.

Published
2021-03-18
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Section
Case Reports
Keywords:
Livedo reticularis, lymphoproliferative disorder, intravascular lymphoma
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How to Cite
Coroado Ferreira, F., Rabadão, T., Naia, L., Teixeira, M., Aveiro, M., Ferreira, G., & Aguiar, D. (2021). The challenging diagnosis of intravascular large B-cell lymphoma. Italian Journal of Medicine, 15(1). https://doi.org/10.4081/itjm.2021.1413