New-onset type 1 diabetes mellitus triggered by SARS-CoV-2 infection in a patient with Hashimoto thyroiditis: a case report

Elena Schipani; Andrea Cozzi; Giuseppe Salvatore Murgida; Valentina Francolini; Eleonora Sisti; Stefania  Di Martino; Francesca Dainelli; Rosa Vecchio; Elisa Grifoni; Luca Masotti

doi:10.4081/itjm.2021.1387

https://doi.org/10.4081/itjm.2021.1387

Elena Schipani Internal Medicine II, San Giuseppe Hospital, Empoli (FI), Italy.
Andrea Cozzi Internal Medicine II, San Giuseppe Hospital, Empoli (FI), Italy. https://orcid.org/0000-0002-9174-9601
Giuseppe Salvatore Murgida Internal Medicine II, San Giuseppe Hospital, Empoli (FI), Italy.
Valentina Francolini Internal Medicine II, San Giuseppe Hospital, Empoli (FI), Italy.
Eleonora Sisti Internal Medicine II, San Giuseppe Hospital, Empoli (FI), Italy.
Stefania Di Martino Internal Medicine II, San Giuseppe Hospital, Empoli (FI), Italy.
Francesca Dainelli Internal Medicine II, San Giuseppe Hospital, Empoli (FI), Italy.
Rosa Vecchio Internal Medicine II, San Giuseppe Hospital, Empoli (FI), Italy.
Elisa Grifoni Internal Medicine II, San Giuseppe Hospital, Empoli (FI), Italy. https://orcid.org/0000-0002-7889-6367
Luca Masotti | luca.masotti@tin.it Internal Medicine II, San Giuseppe Hospital, Empoli (FI), Italy. https://orcid.org/0000-0002-1208-9343

Abstract

New-onset type 1 diabetes mellitus is an uncommon but possible complication triggered by severe acute respiratory syndrome-related coronavirus 2 infection. Metabolic inflammation supported by cytokine storm leading to pancreatic beta cells destruction is the most probable link between coronavirus disease 2019 (COVID-19) and diabetes. Here, we describe the case of a 51-year-old female suffering from Hashimoto thyroiditis, who came to our attention for new-onset polyuria-polydipsia syndrome associated with hyperglycemia after a mild form of COVID-19 recognized two months before and already recovered. Type 1 diabetes was diagnosed.

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References

Baj J, Karakuła-Juchnowicz H, Teresiński G, et al. COVID-19: specific and non-specific clinical manifestations and symptoms: the current state of knowledge. J Clin Med 2020;9:1753.

Azar WS, Njeim R, Fares AH, et al. COVID-19 and diabetes mellitus: how one pandemic worsens the other [published online ahead of print, 2020 Aug 2]. Rev Endocr Metab Disord 2020;1-13.

Rubino F, Amiel SA, Zimmet P, et al. New-onset diabetes in Covid-19 [published online ahead of print, 2020 Jun 12]. N Engl J Med 2020;10.1056/NEJMc2018688.

Ruggeri RM, Campennì A, Siracusa M, et al. Subacute thyroiditis in a patient infected with SARS-COV-2: an endocrine complication linked to the COVID-19 pandemic [published online ahead of print, 2020 Jul 16]. Hormones (Athens) 2020;1-3.

Bornstein SR, Rubino F, Khunti K, et al. Practical recommendations for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrinol 2020;8:546-50.

Ye Q, Wang B, Mao J. The pathogenesis and treatment of the ‘Cytokine Storm’ in COVID-19. J Infect 2020;80:607-13.

Marazuela M, Giustina A, Puig-Domingo M. Endocrine and metabolic aspects of the COVID-19 pandemic [published online ahead of print, 2020 Jul 9]. Rev Endocr Metab Disord 2020;1-13.

Bellastella G, Maiorino MI, Esposito K. Endocrine complications of COVID-19: what happens to the thyroid and adrenal glands?. J Endocrinol Invest 2020;43:1169-70.

Heaney AI, Griffin GD, Simon EL. Newly diagnosed diabetes and diabetic ketoacidosis precipitated by COVID-19 infection [published online ahead of print, 2020 Jun 6]. Am J Emerg Med 2020;S0735-6757(20)30488-5.

Marchand L, Pecquet M, Luyton C. Type 1 diabetes onset triggered by COVID-19 [published online ahead of print, 2020 Jul 11]. Acta Diabetol 2020;1-2.

Chee YJ, Ng SJH, Yeoh E. Diabetic ketoacidosis precipitated by Covid-19 in a patient with newly diagnosed diabetes mellitus. Diabetes Res Clin Pract 2020;164:108166.