Gender differences in ischemic stroke intra-hospital mortality: a systematic review

  • Tiziana Ciarambino | Internal Medicine Department, Hospital of Marcianise, ASL Caserta, Italy.
  • Orazio Valerio Giannico Dipartimento di Prevenzione, ASL Taranto, Italy.
  • Amalia Campanile Department of Internal Medicine, University of Campania L. Vanvitelli, Naples, Italy.
  • Antonella Fischetti Department of Internal Medicine, University of Campania L. Vanvitelli, Naples, Italy.
  • Elena Barabgelata Department of Internal Medicine, Lavagna Hospital, Genova, Italy.
  • Imma Ambrosino Local Healthcare Unit of Bari, Health District 10, Post-acute Care Triggiano, Bari, Italy.
  • Ombretta Para Internal Medicine Department, Ospedale Careggi, University of Florence, Florence, Italy.
  • Cecilia Politi Head of Gender Medicine Area FADOI, Internal Medicine Department, Isernia, Italy.
  • Mauro Giordano Department of Internal Medicine, University of Campania L. Vanvitelli, Naples, Italy.


The aim was to evaluate whether intra-hospital mortality from ischemic stroke is different in female patients. Methods. Studies were found in PubMed, Web of Science. We excluded 119 records because they did not include relevant reports or data. Studies were eligible for inclusion if enrolled adult patients with ischemic stroke and if the odds ratio (OR) of intra-hospital mortality in females compared to males is provided. Three retrospective cohort studies were eligible for inclusion criteria and so were included in the analysis. Findings: the random effect model showed a pooled significant higher risk of intra-hospital mortality [OR 1.34 (95% confidence interval 1.04, 1.74), P=0.026] in the female group compared to the male group. Our systematic review shows that intra-hospital mortality was significantly higher in female subjects compared to male.



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Young FADOI internists: from evidence to clinical practice
Mortality, ischemic stroke, gender/sex differences, not hemorrhagic stroke.
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How to Cite
Ciarambino, T., Giannico, O. V., Campanile, A., Fischetti, A., Barabgelata, E., Ambrosino, I., Para, O., Politi, C., & Giordano, M. (2021). Gender differences in ischemic stroke intra-hospital mortality: a systematic review. Italian Journal of Medicine, 15(2).