Severe paraneoplastic hypoglycemia due to a non-islet cell tumor in a patient with an advanced gastrointestinal stromal tumor

  • Maurizio Alletto Internal Medicine, S. Elia Hospital, Caltanissetta, Italy.
  • Antonio Burgio Internal Medicine, S. Elia Hospital, Caltanissetta, Italy.
  • Giovanni Fulco Internal Medicine, S. Elia Hospital, Caltanissetta, Italy.
  • Giulio Geraci Internal Medicine, S. Elia Hospital, Caltanissetta, Italy.
  • Concetta Groppuso Internal Medicine, S. Elia Hospital, Caltanissetta, Italy.
  • Gianfranco Gruttadauria Internal Medicine, S. Elia Hospital, Caltanissetta, Italy.
  • Elvio Manfrè Internal Medicine, S. Elia Hospital, Caltanissetta, Italy.
  • Gianluca Mastrosimone Internal Medicine, S. Elia Hospital, Caltanissetta, Italy.
  • Susanna Salvaggio Internal Medicine, S. Elia Hospital, Caltanissetta, Italy.
  • Giovanni Urrico Department of Pathology, S. Elia Hospital, Caltanissetta, Italy.
  • Federico Vancheri | fvanche@tin.it Internal Medicine, S. Elia Hospital, Caltanissetta, Italy.

Abstract

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, mainly localized in the stomach. Most GISTs derive from mutations in tyrosine kinase receptors or platelet-derived growth factor receptor-α. GISTs are rarely associated with paraneoplastic hypoglycemia caused by a non-β-cells tumor. This syndrome, defined non-islet cell tumor hypoglycemia (NICTH), arises from excess tumor production of insulin-like growth factor. We describe the case of a 67-year-old female with severe NICTH secondary to an advanced and metastatic GIST.

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Author Biography

Federico Vancheri, Internal Medicine, S. Elia Hospital, Caltanissetta

Internal Medicine, consultant

Published
2020-05-19
Info
Issue
Section
Case Reports
Keywords:
Paraneoplastic hypoglycemia, gastrointestinal stromal tumour, non-islet cell tumor hypoglycemia, insulin-like growth factor.
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How to Cite
Alletto, M., Burgio, A., Fulco, G., Geraci, G., Groppuso, C., Gruttadauria, G., Manfrè, E., Mastrosimone, G., Salvaggio, S., Urrico, G., & Vancheri, F. (2020). Severe paraneoplastic hypoglycemia due to a non-islet cell tumor in a patient with an advanced gastrointestinal stromal tumor. Italian Journal of Medicine, 14(3), 167-171. https://doi.org/10.4081/itjm.2020.1276

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