Bone marrow granulomatosis: two case reports

  • Giacomo Andreani | giacomo.andreani@unito.it Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Italy.
  • Alessandro Morotti Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Italy.
  • Matteo Dragani Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Italy.
  • Francesca Caciolli Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Italy.
  • Bruna Crea Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Italy.
  • Valerio Marci Department of Pathology, San Luigi Gonzaga Hospital, Orbassano (TO), Italy.
  • Ubaldo Familiari Department of Pathology, San Luigi Gonzaga Hospital, Orbassano (TO), Italy.
  • Angelo Guerrasio Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Italy.

Abstract

Bone marrow granulomatosis is not a common finding and remains a diagnostic challenge. Here below we report two bizarre but not so rare cases of bone marrow granulomatosis: bone marrow involvement by Mycobacterium avium-intracellulare and reaction to intravesical administration of Bacillus Calmette-Guérin for non-muscle-invasive bladder cancer; two distinct culprits suggesting the wide range of possible causative factors of this histopathological pattern. In the discussion we provide a brief overview of causes and suggestions for a diagnostic approach.

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Published
2019-06-19
Section
Case Reports
Keywords:
Bacillus Calmette-Guérin, bone marrow granulomatosis, mycobacteria, metallosis, pancytopenia.
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How to Cite
Andreani, G., Morotti, A., Dragani, M., Caciolli, F., Crea, B., Marci, V., Familiari, U., & Guerrasio, A. (2019). Bone marrow granulomatosis: two case reports. Italian Journal of Medicine, 13(3), 181-184. https://doi.org/10.4081/itjm.2019.1150