A case of cryptogenic pseudocirrhosis causing acute liver failure: when clinic and radiology work together

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Martina Finocchi *
Ombretta Para
Giacomo Zaccagnini
Lorenzo Corbo
Lucia Maddaluni
Margherita Giampieri
Eleonora Blasi
Mattia Ronchetti
Carlo Nozzoli
(*) Corresponding Author:
Martina Finocchi | marfihorse@gmail.com

Abstract

It is known that a wild spectrum of hepatic manifestations can be common presentations of metastatic breast cancer. Pseudocirrhosis pattern has been often described as almost always secondary to systemic chemotherapy and it is defined by morphological liver changes that mimic cirrhosis including capsular retraction, nodularity, parenchyma atrophy and caudate lobe, radiologically identifiable. Acute liver injury is an occasional complication in oncologic patients, and it outlines an organ failure when there is evidence of encephalopathy and coagulopathy (international normalized ratio >1.5) in the absence of pre-existing liver disease, with an illness of <26 weeks duration. The two most common etiologies are leukemia/lymphoma followed by breast cancer but also in this case, liver is involved almost always after chemotherapy, hormonotherapy or radiotherapy. Here we present a case of rapid evolving acute liver failure presented as cryptogenic pseudocirrhosis without any evidence of primitive breast cancer but an incidental demonstration.


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