Adipocytokines in metabolically healthy obesity
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The aim of the investigation was to study the relationship among adipokines, markers of subclinical inflammation and endothelial dysfunction in patients with metabolic healthy obesity (MHO). The study included 50 persons aged 25-50 years with obesity in the absence of metabolic disorders (International Diabetes Federation criteria, 2005, marked as MHO), the control group consisted of 50 healthy respondents without obesity. We studied clinical and biochemical parameters, insulin resistance index (HOMA-IR), levels of leptin, soluble leptin receptors (sLR), resistin, adiponectin, C-reactive protein (CRP-hs), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), von Willebrand factor, free leptin index was calculated in a formula (FLI = leptin — 100 / sLR). In MHO patients, independently of HOMA-IR index, there was an increase in leptin, FLI, resistin, VEGF, and IL-6 parameters. The concentration of CRP-hs and TNF-α in MHO group with HOMA-IR ‰¥2.7 was increased. Systolic blood pressure correlated with leptin level (r=0.43, P<0.05), FLI (r=0.54; P=0.01), TNF-α (r=0.44; P<0.05) and IL-6 (r=0.33; P<0.05); diastolic blood pressure - with leptin level (r=0.35, P<0.05). Links between high density lipoproteins and leptin (r=-0.55 and r=-0.60; P<0.01), resistin (r=0.32; P<0.05 and r=0.60; P<0.01) and VEGF (r=-0.70, P<0.01) were established. The VEGF level correlated with HOMA-IR (r=0.62; P<0.01), leptin (r=0.29; P<0.05), FLI (r=0.50; P<0.05), resistin (r=0.70; P<0.01), IL-6 (r=0.74, P<0.01) and ET-1 (r=0.29; P<0.05). Obese patients without metabolic disorders, having normotension and normal insulin sensitivity, are less influenced to adverse cardiovascular risks due to less expressed hormonal and inflammatory activation of adipose tissue and, as a result, less pronounced endothelial dysfunction. While insulin resistance develops, cardiovascular risk increases due to activation of subclinical inflammation, angiogenic endothelial dysfunction and leptin resistance.
Altmetrics
Downloads
Citations
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Iranna Kotturshetti, Basavaraj Vastrad, Veena Kori, Chanabasayya Vastrad, Shivakumar Kotrashetti, Screening of the key genes and signaling pathways for schizophrenia using bioinformatics and next generation sequencing data analysis , Italian Journal of Medicine: Vol. 18 No. 4 (2024)
- Fatjona Gashi, Muhamet Kadrija, Zafer Gashi, Mila Arapcheska, Shkelzen Elezaj, Fitore Gashi, Fitim Gashi, Gentian Elezaj, Liridon Elezaj, Correlation between diet, body mass index, and lipid profile in Kosovar women treated for primary infertility , Italian Journal of Medicine: Vol. 18 No. 3 (2024)
- Manuel Monti, Maria Pia Ruggieri, Giovanni Maria Vincentelli, Fernando Capuano, Francesco Rocco Pugliese, Cardiovascular risk factors in sub-Saharan Africa: a review , Italian Journal of Medicine: Vol. 9 No. 4 (2015)
- Elena Nikolaevna Smirnova, Evgeniya Alexandrovna Loran, Sofia Grigorievna Shulkina, Sergey Yurievich Podtaev, Maxim Victorovich Trushin, Endothelial dysfunction and reduced heart rate variability in patients with metabolic syndrome , Italian Journal of Medicine: Vol. 12 No. 1 (2018)
- Vincenzo Trapanese, Maria Chiara Pelle, Maria Capria, Nazareno Carullo, Clara Vatalaro, Francesca Cosentino, Melania Melina, Maria Resilde Natale, Federica Giofrè, Franco Arturi, Impressive weight loss induced by a very low-calorie ketogenic diet in a morbidly complex obese patient with a recent episode of acute kidney injury and advanced chronic kidney disease: a case report , Italian Journal of Medicine: Vol. 18 No. 3 (2024)
- Manuel Monti, Roberto Marchetti, Giovanni Maria Vincentelli, Epicardial fat, gender, and cardiovascular risk , Italian Journal of Medicine: Vol. 15 No. 2 (2021)
- Nathan Artom, Giuliano Pinna, The erectile dysfunction as a cardiovascular risk factor , Italian Journal of Medicine: Vol. 8 No. 4 (2014)
- Zafer Gashi, Muhamet Kadrija, Pathological changes of biochemical, hematological and coagulation analyses in patients with COVID-19 disease , Italian Journal of Medicine: Vol. 18 No. 2 (2024)
- Flavio Cursi, Folate deficiency and psycho-organic syndrome in elderly subjects: review of the literature , Italian Journal of Medicine: Vol. 12 No. 2 (2018)
- Sirio Fiorino, Andrea Carusi, Alessandro Zappi, Fabio Tateo, Luca Peruzzo, Melissa Zanardi, Francesco Savelli, Giulia Di Marzio, Silvia Cesaretti, Francesca Dazzani, Raffaella Francesconi , Paolo Leandri , Gianfranco Tortorici , Susanna Vicari , Dora Melucci, Federico Lari, Characteristics, comorbidities and laboratory measures associated with disease severity and poor prognosis in young and elderly patients with COVID-19 admitted to medical wards in Emilia-Romagna region, Italy: a multicentre retrospective study , Italian Journal of Medicine: Vol. 17 No. 1 (2023)
You may also start an advanced similarity search for this article.