Acute granulomatous interstitial nephritis and ulcerative colitis: a case report and literature review

  • Giorgia Comai Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
  • Olga Baraldi Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
  • Vania Cuna Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
  • Valeria Corradetti Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
  • Maria Cappuccilli Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
  • Marco Busutti Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
  • Deborah Malvi Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
  • Benedetta Fabbrizio Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
  • Massimo Campieri Department of Clinical Medicine, S. Orsola Malpighi Hospital, University of Bologna, Bologna, Italy.
  • Gaetano La Manna | gaetano.lamanna@unibo.it Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Abstract

Tubulo-interstitial nephritis (TIN) in patients affected by inflammatory bowel disease, both ulcerative colitis and Crohn’s disease, is usually considered as drug-associated to aminosalicylate. We report a rare case of granulomatous active tubulo-interstitial nephritis in a young patient with a recent diagnosis of ulcerative colitis naïve to aminosalicylate treatment. The patient has been successfully treated with steroids administration. Our purpose is to sensitize that TIN should always to be considered in differential diagnosis an extra-intestinal manifestation of bowel disease.

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Author Biographies

Giorgia Comai, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna
Nephrologist
Olga Baraldi, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna
Nephrologist
Vania Cuna, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna
Nephrologist
Valeria Corradetti, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna
Nephrologist
Maria Cappuccilli, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna
Biochemist
Marco Busutti, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna
Specializing nephrologist
Deborah Malvi, Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna
Anatomopathologist
Benedetta Fabbrizio, Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna
Anatomopathologist
Massimo Campieri, Department of Clinical Medicine, S. Orsola Malpighi Hospital, University of Bologna, Bologna
Full Professor of Gastroenterology
Published
2018-03-20
Info
Issue
Section
Case Reports
Keywords:
Aminosalicylate therapy, inflammatory bowel disease, tubulo-interstitial nephritis, steroid therapy.
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How to Cite
Comai, G., Baraldi, O., Cuna, V., Corradetti, V., Cappuccilli, M., Busutti, M., Malvi, D., Fabbrizio, B., Campieri, M., & La Manna, G. (2018). Acute granulomatous interstitial nephritis and ulcerative colitis: a case report and literature review. Italian Journal of Medicine, 12(1), 57-60. https://doi.org/10.4081/itjm.2018.929