Sex differences in adverse drug reaction and liver disease

  • Ombretta Para | parao@aou-careggi.toscana.it Department of Internal Medicine, Careggi Hospital, Firenze, Italy.
  • Pietro Crispino Department of Internal Medicine, San Carlo Hospital, Potenza, Italy.
  • Nunzia Barone Department of Internal Medicine, San Carlo Hospital, Potenza, Italy.
  • Sara Macis Hospital Pharmacy, San Paolo Hospital, Savona, Italy.
  • Laura Airasca Hospital Pharmacy, San Paolo Hospital, Savona, Italy.
  • Paola Gnerre Department of Internal Medicine, San Paolo Hospital, Savona, Italy.
  • Cecilia Politi Department of Internal Medicine, Hospital of Isernia, Italy.

Abstract

Adverse drug reactions represent a significant public health problem. A share of no small adverse reaction is particularly serious and can even lead to patient’s death. Furthermore, hepatitis induced by serious drug reactions is a rare event but potentially fatal. Finally, we know that epidemiological studies have highlighted male gender as an independent predictor of fibrosis progression towards cirrhosis in hepatitis B and C-virus, as well as non-alcoholic steatohepatitis. The importance of considering the differences between the male and female sex in clinical decision-making is crucial. The physiopathology of liver disease is different in the two genres, but these differences are not yet fully known and several potential mechanisms have been identified.

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Published
2018-03-20
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Issue
Section
Reviews
Keywords:
Adverse drug reactions, drug-induced liver injury, liver disease, chronic hepatitis.
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How to Cite
Para, O., Crispino, P., Barone, N., Macis, S., Airasca, L., Gnerre, P., & Politi, C. (2018). Sex differences in adverse drug reaction and liver disease. Italian Journal of Medicine, 12(1), 15-22. https://doi.org/10.4081/itjm.2018.893

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