Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature

  • Nathan Artom Department of Internal Medicine, San Paolo Hospital, Savona, Italy.
  • Marcello Brignone Department of Internal Medicine, San Paolo Hospital, Savona, Italy.
  • Luca Paris Department of Internal Medicine, San Paolo Hospital, Savona, Italy.
  • Anna Lisa Garlaschelli Department of Internal Medicine, San Paolo Hospital, Savona, Italy.
  • Marina Cavaliere Department of Internal Medicine, San Paolo Hospital, Savona, Italy.
  • Gian Luca Michelis Department of Internal Medicine, San Paolo Hospital, Savona, Italy.
  • Claudia Venturino Department of Internal Medicine, San Paolo Hospital, Savona, Italy.
  • Silvia Ardoino Department of Clinical Pathology, San Paolo Hospital, Savona, Italy.
  • Ezio Venturino Department of Clinical Pathology, San Paolo Hospital, Savona, Italy.
  • Paola Gnerre | pgnerre@yahoo.it Department of Internal Medicine, San Paolo Hospital, Savona, Italy.
  • Rodolfo Tassara Department of Internal Medicine, San Paolo Hospital, Savona, Italy.

Abstract

Castleman disease (CD) is a rare lymphoproliferative disorder also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia. CD can be unicentric CD (UCD) or multicentric CD (MCD). MCD affects more than one group of lymph nodes and/or lymphoid tissues and it is frequently associated with HIV and human herpes virus 8 (HHV-8) infections and, in contrast with UCD, it often results in systemic symptoms, such as fever, fatigue, anemia, inflammatory syndrome. HHV- 8-associated MCD recognizes HHV-8 as an etiopathogenetic agent and occurs generally in HIV-positive subjects. Our report describes an HHV-8 positive Castleman disease with plasmablastic microlymphoma occurring in a 51-year-old HIV seronegative woman, with a previous history of HBV infection and Kaposi’s sarcoma, who presented elevated procalcitonin levels during the acute phase of CD.

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Published
2018-12-04
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Section
Case Reports
Keywords:
Castleman disease, lymphoproliferative disorder, multicentric Castleman disease.
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How to Cite
Artom, N., Brignone, M., Paris, L., Garlaschelli, A. L., Cavaliere, M., Michelis, G. L., Venturino, C., Ardoino, S., Venturino, E., Gnerre, P., & Tassara, R. (2018). Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature. Italian Journal of Medicine, 12(4), 276-279. https://doi.org/10.4081/itjm.2018.1063

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