Transient idiopathic central diabetes insipidus: is severe sepsis a possible cause?

  • Ilaria Lazzari | ilaria.lazzari17@gmail.com Department of Internal Medicine, Sant’Orsola Hospital, Bologna, Italy.
  • Alessandro Graziani Department of Internal Medicine, Faenza Hospital, Faenza (RA), Italy.
  • Federica Mirici Department of Internal Medicine, Faenza Hospital, Faenza (RA), Italy.
  • Giuseppe Francesco Stefanini Department of Internal Medicine, Faenza Hospital, Faenza (RA), Italy.

Abstract

Idiopathic central diabetes insipidus (CDI) is a disorder characterized by hypotonic polyuria and polydipsia, without any identified etiology. Here we report a case of a 57-year-old woman, with idiopathic CDI, admitted to our department with severe sepsis and acute kidney failure. After clinical and radiological investigations, she was diagnosed with idiopathic CDI. In this case report the findings suggest that severe sepsis could be the trigger for this disease. In addition, we hypothesise that apelin, a diuretic neuropeptide, plays a role in such a process. Apelin levels are known to increase during severe sepsis, which in turn counteracts vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release.

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Published
2017-03-15
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Issue
Section
Case Reports
Keywords:
Central diabetes insipidus, vasopressin, severe sepsis, apelin.
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How to Cite
Lazzari, I., Graziani, A., Mirici, F., & Stefanini, G. F. (2017). Transient idiopathic central diabetes insipidus: is severe sepsis a possible cause?. Italian Journal of Medicine, 11(1), 78-81. https://doi.org/10.4081/itjm.2017.717