Management of sepsis: from evidence to clinical practice

  • Riccardo Gerloni | Department of Internal Medicine, Cattinara Hospital, Trieste, Italy.
  • Luciano Mucci Department of Internal Medicine, Ospedali Riuniti Marche Nord, Fano (PU), Italy.
  • Carlotta Casati Department of Internal Medicine, Careggi Hospital, Firenze, Italy.
  • Andrea Crociani Department of Internal Medicine, Careggi Hospital, Firenze, Italy.
  • Ombretta Para Department of Internal Medicine, Careggi Hospital, Firenze, Italy.
  • Elisabetta Benetti Emergency Department, San Bassiano Hospital, Bassano del Grappa (VI), Italy.
  • Paola Gnerre Department of Internal Medicine, San Paolo Hospital, Savona, Italy.
  • Anna Bovero Department of Internal Medicine, Santa Corona Hospital, Pietra Ligure (SV), Italy.
  • Elisa Romagnoli Department of Internal Medicine, Paulo nel Frignano Hospital, Modena, Italy.
  • Nicola Tarquinio Department of Internal Medicine, S.S. Benvenuto e Rocco Hospital, Osimo (AN), Italy.
  • Clelia Canale Department of Internal Medicine, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy.
  • Davide Brancato Department of Internal Medicine, Ospedale Civico, Partinico (PA), Italy.
  • Laura Massarelli Department of Internal Medicine, C. Massaia Hospital, Asti, Italy.
  • Salvatora Piras Department of Internal Medicine, ASL 1 Sassari, Alghero (SS), Italy.


Sepsis is one of the leading causes of death in hospitalized patients and its management involves a lot of specialist. Internist is required to demonstrate his competence since the beginning when the diagnosis is not so easy to be clarified. A rapid clinical suspicion permits a prompt management of the patient that means important mortality reduction. However, it is essential to understand the source of infection and echography represents a rapid, economic, useful and widespread tool with whom Internist should become more and more confident. The following review is a practical guide to manage septic patients according to the most recent literature, underlining aspects of antibiotic therapy, hemodynamic stabilization and supportive therapy. To limit sepsis mortality, a valid Internist should be culturally prepared and especially able to cooperate with other specialists, because a strong enemy requires a strong team.


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Sepsis, severe sepsis, septic shock.
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How to Cite
Gerloni, R., Mucci, L., Casati, C., Crociani, A., Para, O., Benetti, E., Gnerre, P., Bovero, A., Romagnoli, E., Tarquinio, N., Canale, C., Brancato, D., Massarelli, L., & Piras, S. (2016). Management of sepsis: from evidence to clinical practice. Italian Journal of Medicine, 10(4), 308-328.

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