Pancreatic carcinoma development: new etiological and pathogenetic evidence

  • Sirio Fiorino | sirio.fiorino@ausl.bo.it UO di Medicina Interna, Ospedale di Budrio, Budrio (BO), Italy.
  • Letizia Bacchi-Reggiani Istituto di Cardiologia, Policlinico S. Orsola Malpighi, Università degli Studi di Bologna, Italy.
  • Laura Pontoriero UO Materno Infantile, Distretto Lametino, ASP, Catanzaro, Italy.
  • Claudio Gallo Medico Specialista in Malattie Infettive, Italy.
  • Elisabetta Chili UO di Anestesia e Rianimazione, Azienda Ospedaliera-Universitaria, Policlinico di Modena, Modena, Italy.
  • Michele Masetti UO di Chirurgia A, Ospedale Maggiore, Bologna, Italy.
  • Nicola Zanini UO di Chirurgia A, Ospedale Maggiore, Bologna, Italy.
  • Anna Grondona Laboratorio Centralizzato, Ospedale Maggiore, Bologna, Italy.
  • Tania Silvestri Laboratorio Centralizzato, Ospedale Maggiore, Bologna, Italy.
  • Gaia Deleonardi Laboratorio Centralizzato, Ospedale Maggiore, Bologna, Italy.
  • Elisabetta Magrini Laboratorio Centralizzato, Ospedale Maggiore, Bologna, Italy.
  • Roberto Motta Laboratorio Centralizzato, Ospedale Maggiore, Bologna, Italy.
  • Adele Fornelli Servizio di Anatomia Patologica, Ospedale Maggiore, Bologna, Italy.
  • Arrigo Bondi Servizio di Anatomia Patologica, Ospedale Maggiore, Bologna, Italy.
  • Dario De Biase Servizio di Anatomia Patologica, Ospedale Bellaria, Bologna, Italy.
  • Paola Baccarini Servizio di Anatomia Patologica, Ospedale Bellaria, Bologna, Italy.
  • Giovanni Tallini Servizio di Anatomia Patologica, Ospedale Bellaria, Bologna, Italy.
  • Antonio Tropeano Specialista in Odontoiatria, Italy.
  • Andrea Cuppini UO di Medicina Interna, Ospedale di Budrio, Budrio (BO), Italy.
  • Gastone Castellani Istituto di Fisica, Università degli Studi di Bologna, Italy.
  • Elio Jovine UO di Chirurgia A, Ospedale Maggiore, Bologna, Italy.

Abstract

Pancreatic adenocarcinoma (PAC) is a very aggressive cancer with a poor prognosis. To date, the causes and pathogenetic mechanisms involved in the development of this malignancy remain largely unknown. Therefore, additional studies are required to improve our knowledge of the events that occur during the process of pancreatic carcinogenesis. The purpose of this article is to describe the most recent evidence, concerning the possible risk factors and mechanisms that may contribute to determine the development of PAC, as well as models, such as the tensegrity model, that may explain this complex process. Available studies suggest that approximately 15-20% of human malignancies are somehow associated with chronic infection. Some epidemiological research has shown that some infectious agents represent risk factors for PAC. In particular, several reports showed that the infection caused by some micro-organisms, including helicobacter pylori and some bacterial species of oral microbiota, as well as by viral agents, such as human immunodeficiency virus (HIV), and hepatitis B (HBV) and C (HCV) viruses, is associated with an increased probability of developing PAC. For the first time, observational studies and meta-analyses have suggested that HBV and HCV, two hepatotropic viruses with oncogenic properties, may be also risk factors for PAC. However, the small number of available reports, nearly all performed in Asian populations, limits their validity to these ethnic groups. Therefore, additional studies focusing on populations of different geographical areas and enrolling larger series of patients are required to confirm this association. Furthermore, an accurate description and a better understanding of the events and of the pathogenetic mechanisms involved in the process of pancreatic carcinogenesis, as proposed by the tensegrity model, might be a useful approach to effectively deal with this pathology.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2013-12-17
Info
Issue
Section
Reviews
Keywords:
pancreatic carcinoma, hepatitis B virus, hepatitis C virus, tensegrity, immune response.
Statistics
  • Abstract views: 1469

  • PDF: 821
  • HTML: 214
How to Cite
Fiorino, S., Bacchi-Reggiani, L., Pontoriero, L., Gallo, C., Chili, E., Masetti, M., Zanini, N., Grondona, A., Silvestri, T., Deleonardi, G., Magrini, E., Motta, R., Fornelli, A., Bondi, A., De Biase, D., Baccarini, P., Tallini, G., Tropeano, A., Cuppini, A., Castellani, G., & Jovine, E. (2013). Pancreatic carcinoma development: new etiological and pathogenetic evidence. Italian Journal of Medicine, 7(4), 242-252. https://doi.org/10.4081/itjm.2013.242