https://doi.org/10.4081/itjm.2024.1696

Trabecular bone score in obese patients with and without diabetes

Vol. 18 No. 1 (2024)
Published: 5 February 2024
Obesity, diabetes, trabecular bone density
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Authors

Gordana Dzeletovic
gordanadzeletovic@gmail.com
Military Hospital, Novi Sad, Serbia.
Aleksandar Jovanovic
https://orcid.org/0000-0002-5461-4978
Faculty of Medicine, University of Pristina - Kosovska Mitrovica, Kosovo.
Tatjana Novakovic
https://orcid.org/0000-0001-7434-1877
Faculty of Medicine, University of Pristina - Kosovska Mitrovica, Kosovo.
Snezana Markovic-Jovanovic
https://orcid.org/0000-0003-3010-2668
Faculty of Medicine, University of Pristina - Kosovska Mitrovica, Kosovo.
Emilija Novakovic
https://orcid.org/0000-0001-8000-7955
Faculty of Medicine, University of Pristina - Kosovska Mitrovica, Kosovo.
Anja Dzeletovic
https://orcid.org/0009-0006-2866-832X
Faculty of Medicine, Novi Sad, Serbia.
Milena Lukić
Cord IPS, Novi Sad, Serbia.
Biljana Kostic-Inic
Clinical Hospital Centre, Pristina, Gračanica, Kosovo.
Sanja Jovanovic
https://orcid.org/0000-0001-5605-1083
Faculty of Medicine, University of Pristina - Kosovska Mitrovica, Kosovo.
Miljan Jankovic
https://orcid.org/0009-0003-3067-5340
Faculty of Medicine, University of Pristina - Kosovska Mitrovica, Kosovo.

The link between obesity, diabetes and bone metabolism is quite complex and not entirely clear. Although many clinical and epidemiological studies demonstrate that obesity enhances bone mineral density, its effect on bone microarchitecture is uncertain. The objective of this study was to examine the bone microarchitecture in obese patients with and without diabetes. The study included 119 individuals with ages from 30 to 50. Participants were divided into three groups: obese patients, obese diabetic patients, and a healthy control group. Results showed that obesity has a positive effect on trabecular bone score (TBS). Diabetes and obesity have a significant interactive impact on bone microarchitecture (TBS). Furthermore, HbA1c influences TBS in both obese diabetic patients and obese non-diabetic subjects. In contrast to the majority of studies, we found that obesity positively influenced TBS. TBS was inversely related to HbA1c levels in obese type 2 diabetics. Diabetes and obesity have a significant interactive impact on bone structure, in particular on bone microarchitecture.

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Citations

Crossref
Scopus
Google Scholar
Europe PMC
Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. Eur J Rheumatol 2017;4:46-56. DOI: https://doi.org/10.5152/eurjrheum.2016.048
Unnanuntana A, Gladnick BP, Donnelly E, Lane JM. The assessment of fracture risk. J Bone Joint Surg Am 2010;92:743-53. DOI: https://doi.org/10.2106/JBJS.I.00919
Vestergaard P, Rejnmark L, Mosekilde L. Osteoporosis is markedly underdiagnosed: a nationwide study from Denmark. Osteoporos Int 2005;16:134-41. DOI: https://doi.org/10.1007/s00198-004-1680-8
Hodgson SF, Watts NB, Bilezikian JP, et al. American Assotiation of Clinical Endrocrinologists Medical Guidelines for Clinical Practice for the prevention and treatment of postmenopausal osteoporosis: 2001 edition, with selected updates for 2003. Endocr Pract 2003;9:544-64. DOI: https://doi.org/10.4158/EP.9.6.544
Compston J, Cooper A, Cooper, et al. Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas 2009;62:105-8. DOI: https://doi.org/10.1016/j.maturitas.2008.11.022
Gkastaris K, Goulis DG, Potoupnis M, et al. Obesity, osteoporosis and bone metabolism. J Musculoskelet Neuronal Interct 2020;20:372-81.
Turcotte AF, O Connor S, Morin SN, et al. Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis. PLoS One 2021;16:e0252487. DOI: https://doi.org/10.1371/journal.pone.0252487
Brown JP, Josse RG. Clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 2002;167:S1-34.
Schwartz AV. Diabetes Mellitus: Does it Affect Bone? Calcif Tissue Int 2003;73:515-9. DOI: https://doi.org/10.1007/s00223-003-0023-7
Leidig-Bruckner G, Ziegler R. Diabetes mellitus a risk for osteoporosis? Exp Clin Endocrinol Diabetes 2001;109:S493-514. DOI: https://doi.org/10.1055/s-2001-18605
Garnero P, Sornay-Rendu E, Claustrat B, Delmas PD. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner Res 2000;15:1526-36. DOI: https://doi.org/10.1359/jbmr.2000.15.8.1526
Evans AL, Paggiosi MA, Eastell R, Walsh JS. Bone density, microstructure and strength in obese and normal weight men and women in younger and older adulthood. J Bone Miner Res 2015;30:920-8. DOI: https://doi.org/10.1002/jbmr.2407
Leeners B, Geary N, Τobler P, Asarian L. Ovarian hormones and obesity. Human Reproduction Update 2017;23:300-21. DOI: https://doi.org/10.1093/humupd/dmw045
Kemink SA, Hermus AR, Swinkels LM, et al. Osteopenia in insulin-dependent diabetes mellitus; prevalence and aspects of pathophysiology. J Endocrnol Invest 2000;23:295-303. DOI: https://doi.org/10.1007/BF03343726
Compston JE, Watts NB, Chapurlat R, et al. Obesity is not protective against fracture in postmenopausal women: GLOW. Ame J Med 2011;124:1043-50. DOI: https://doi.org/10.1016/j.amjmed.2011.06.013
Romagnoli E, Lubrano C, Carnevale V, et al. Assessment of trabecular bone score (TBS) in overweight/ obese men: effect of metabolic and anthropometric factors. Endocrine 2016;54:342-7. DOI: https://doi.org/10.1007/s12020-016-0857-1
Rinonapoli G, Pace V, Ruggiero C, et al. Obesity and Bone: A Complex Relationship. Int J Mol Sci 2021;22:13662. DOI: https://doi.org/10.3390/ijms222413662
Qiao D, Li Y, Liu X, et al. Association of obesity with bone mineral density and osteoporosis in adults: a systematic review and meta-analysis. Pub Health 2020:180:22-8. DOI: https://doi.org/10.1016/j.puhe.2019.11.001
Xiu S, Mu Z, Sun L, et al. Hemoglobin level and osteoporosis in Chinese elders with type 2 diabetes mellitus. Nutr Diabetes 2022;12:19. DOI: https://doi.org/10.1038/s41387-022-00198-z
Shih CW, Fang WH, Chen WL. Clinical relevance of the relationship between Trabecular Bone Score and metabolic syndrome. J Investig Med 2022;70:967-71. DOI: https://doi.org/10.1136/jim-2021-002009
Taderegew MM, Gebremariam T, Tareke AA, Woldeamanuel GG. Anemia and Its Associated Factors Among Type 2 Diabetes Mellitus Patients Attending Debre Berhan Referral Hospital, North-East Ethiopia: A Cross-Sectional Study. J Blood Med 2020;11:47-58. DOI: https://doi.org/10.2147/JBM.S243234

How to Cite

Dzeletovic, G., Jovanovic, A., Novakovic, T., Markovic-Jovanovic, S., Novakovic, E., Dzeletovic, A., Lukić, M., Kostic-Inic, B., Jovanovic, S., & Jankovic, M. (2024). Trabecular bone score in obese patients with and without diabetes. Italian Journal of Medicine, 18(1). https://doi.org/10.4081/itjm.2024.1696
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