https://doi.org/10.4081/itjm.2023.1563

Association of β2 microglobulin level and glomerular filtration rate in patients with acute leukemia after hematopoietic stem cell transplantation

Vol. 17 No. 1 (2023)
Submitted: 17 December 2022
Accepted: 20 January 2023
Published: 16 February 2023
Hematopoietic stem cell transplantation, acute leukemia, β2 microglobulin, glomerular filtration rate, biomarkers of renal function.
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Authors

Aigerim O. Murzakhmetova
sapen4ic@mail.ru
https://orcid.org/0000-0002-1487-5487
Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Astana, Kazakhstan.
Vitaly B. Kamkhen
Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Ayagul M. Ainabay
Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Astana; National Research Oncology Center, Astana, Kazakhstan.
Assel M. Meiramova
Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Astana, Kazakhstan.
Vadim M. Kemaykin
National Research Oncology Center, Astana, Kazakhstan.
Bayan A. Ainabekova
Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Astana, Kazakhstan.

Hematopoietic stem cell transplantation is a life-saving therapy in patients suffering from acute leukemia. However, kidney complications developed after performing hematopoietic stem cell transplantation can affect the course and prognosis of the disease in patients with acute leukemia. This study is aimed at assessing the functional status of the kidneys in patients with acute leukemia who have undergone hematopoietic stem cell transplantation. The study has observed a group of patients with acute lymphoblastic leukemia and acute myeloid leukemia who have undergone hematopoietic stem cell transplantation. It has been discovered that β2 microglobulin is a sensitive method of analyzing renal function, with the β2 microglobulin threshold urine level not exceeding 0.3 mg/L. The complex diagnostics of kidney function in hematopoietic stem cell transplantation recipients has given the opportunity to identify the relationship between increased β2 microglobulin levels and decreased glomerular filtration rate. It has been determined that β2 microglobulin is a biomarker of renal disorders. The obtained data have showed that β2 microglobulin can be used as a diagnostic marker of reduced kidney function.

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How to Cite

Murzakhmetova, A. O., Kamkhen, V. B., Ainabay, A. M., Meiramova, A. M., Kemaykin, V. M., & Ainabekova, B. A. (2023). Association of β<sub>2</sub> microglobulin level and glomerular filtration rate in patients with acute leukemia after hematopoietic stem cell transplantation. Italian Journal of Medicine, 17(1). https://doi.org/10.4081/itjm.2023.1563
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