https://doi.org/10.4081/itjm.2020.1435

Potential pharmacological approach in the regulation of angiotensin-II conversion enzyme and dipeptidyl-peptidase 4 in diabetic COVID-19 patients

Vol. 15 No. 1 (2021)
Submitted: 25 November 2020
Accepted: 3 December 2020
Published: 28 December 2020
Diabetes, COVID-19, SARS-CoV-2, angiotensin- II conversion enzyme, dipeptidyl-peptidase 4.
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Authors

Francesco Ferrara
francesco.ferrara@uslumbria1.it
https://orcid.org/0000-0001-9298-6783
Hospital Pharmacist Manager, Pharmaceutical Department, Usl Umbria 1, Perugia, Italy.
Antonio Vitiello
Clinical Pharmacologist, Pharmaceutical Department, Usl Umbria 1, Perugia, Italy.

The global pandemic caused by coronavirus disease 2019 (COVID-19) has caused more than 1 million deaths worldwide. Some vaccines in clinical trials have reached stage 3. In the meantime, the understanding of biological and pathophysiological mechanisms of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection is still unclear, such as the role that angiotensin-II conversion enzyme (ACE-2) and dipeptidyl-peptidase 4 (DPP-IV) may play in patients with diabetes related to COVID-19. The individual with diabetes is a known COVID-19 risk patient. Probably, the pharmacological regulation of the angiotensin renin system and ACE-2 on the one hand, and of the incretin system and DPP-IV on the other hand, could represent a therapeutic route of fundamental importance to reduce the risk of SARS-CoV-2 infection or of severe complications caused by infection.

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How to Cite

Ferrara, F., & Vitiello, A. (2020). Potential pharmacological approach in the regulation of angiotensin-II conversion enzyme and dipeptidyl-peptidase 4 in diabetic COVID-19 patients. Italian Journal of Medicine, 15(1). https://doi.org/10.4081/itjm.2020.1435

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