Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia

Submitted: 20 May 2020
Accepted: 8 June 2021
Published: 24 September 2021
Abstract Views: 955
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Authors

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disease that manifests with chronic intravascular hemolysis, thrombosis, and bone marrow failure. Various degrees of cytopenias accompany the disease. Although laboratory and clinical findings are similar, the disease may show different courses and require different treatments. Herein, we report two different courses of PNH with similar clinical and laboratory findings.

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Citations

Sahin F, Akay OM, Ayer M, et al. Pesg PNH diagnosis, follow-up and treatment guidelines. Am J Blood Res 2016;6:19-27.
Borowitz MJ, Craig FE, Digiuseppe JA, et al. Guidelines for the diagnosis and monitoring of par-oxysmal nocturnal hemoglobinuria and related disorders by flow cytometry. Cytometry B Clin Cytom 2010;78:211-30. DOI: https://doi.org/10.1002/cyto.b.20525
Kulagin A, Lisukov I, Ivanova M, et al. Prognostic value of paroxysmal nocturnal haemoglobinuria clone presence in aplasticanaemia patients treated with combined immunosuppression: results of two-centreprospective study. Br J Haematol 2014;164:546-54.
Ogawa S. Clonal hematopoiesis in acquired aplastic anemia. Blood. 2016;128:337-47. DOI: https://doi.org/10.1182/blood-2016-01-636381
Yoshizato T, Dumitriu B, Hosokawa K, et al. Somatic mutations and clonal hematopoiesis in aplas-tic anemia. N Engl J Med 2015;373:35-47. DOI: https://doi.org/10.1056/NEJMc1509703
Kulagin A, Lisukov I, Ivanova M, et al. Prognostic value of paroxysmal nocturnal haemoglobinuria clone presence in aplastic anaemia patients treated with combined immunosuppression: results of two-centre prospective study. Br J Haematol 2014;164:546-54. DOI: https://doi.org/10.1111/bjh.12661
Devalet B, Mullier F, Chatelain B, et al. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review. Eur J Haematol 2015;95:190-8. DOI: https://doi.org/10.1111/ejh.12543
Lee SE, Park SS, Jeon YW, et al. Outcomes of allogeneic stem cell transplantation in patients with paroxysmal nocturnal hemoglobinuria with or without aplastic anemia. Eur J Haematol 2017;99:336-43. DOI: https://doi.org/10.1111/ejh.12922
Asano J, Ueda R, Tanaka Y, et al. Effects of immunosuppressive therapy in a patient with aplastic anemia-paroxysmal nocturnal hemoglobinuria (AA-PNH) syndrome during ongoing eculizumab treatment. Intern Med 2014;53:125-8. DOI: https://doi.org/10.2169/internalmedicine.53.0684

How to Cite

Karakuş, V., Kaya, E., Dere, Y., & Åžahin, F. (2021). Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia. Italian Journal of Medicine, 15(3). https://doi.org/10.4081/itjm.2021.1319