https://doi.org/10.4081/itjm.2025.1875

Role of platelet indices and vitamin D in forecasting deterioration of glycemic control and vascular complications in type 2 diabetes

Vol. 19 No. 1 (2025)
Published: 20 January 2025
Diabetes, platelet indices, vitamin D, vascular complications, glycemic control
Abstract Views: 31
PDF: 16
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Authors

Maryam Ahmed Obaid Al Ali
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Khalid Abdelsamea Mohamedahmed
https://orcid.org/0000-0001-7084-6106
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jerash University, Jordan; Department of Hematology and Immunology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan.
Asaad Ma Babker
azad.88@hotmail.com
https://orcid.org/0000-0002-5022-5676
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.

Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition associated with various complications, including vascular ones. Platelet indices and vitamin D have been proposed as potential predictors of glycemic control deterioration and vascular complications in T2DM patients. This study aimed to investigate the predictive role of platelet indices and vitamin D in the development of vascular complications and deterioration of glycemic control in type 2 diabetic patients attending Thumbay Hospital, Ajman. In this cross-sectional study, data were collected from individuals divided into two groups: a controlled group and a patient group with T2DM from the Thumbay Hospital and Thumbay Laboratory. A total of 100 individuals aged between 20 and 75 years was included. Demographic information, vitamin D levels, and platelet indices were collected and analyzed using appropriate statistical tests. The demographic distribution of T2DM patients revealed that males accounted for 56.76% of the sample, while females represented 43.22%. The analysis of vitamin D levels showed that 58% had a deficiency, 23% had an insufficiency, and 19% fell within the optimal range. Platelet indices were evaluated in relation to glycemic control, and significant associations were found between vitamin D levels and mean platelet volume (MPV) as well as platelet distribution width (PDW). Post-hoc tests indicated significant differences in plateletcrit values among specific glycemic control groups. Furthermore, diabetic patients had significantly higher levels of fasting blood glucose and hemoglobin A1C compared to the control group, along with higher MPV and slightly lower PDW. The findings suggest a potential predictive role of platelet indices and vitamin D in the deterioration of glycemic control and the development of vascular complications in T2DM patients attending Thumbay Hospital, Ajman.

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Citations

Crossref
Scopus
Google Scholar
Europe PMC
Altoum AEA, Osman AL, Babker AM. Correlation of oxidative stress markers malondialdehyde (MDA), antioxidant vitamins A, E, and C with glycated hemoglobin (HBA1C) levels in Type 2 diabetes mellitus. Asian J Pharm Clin Res 2018;11:281-3. DOI: https://doi.org/10.22159/ajpcr.2018.v11i5.24548
Mohamed H, Abbas AM, Huneif MA, et al. Influence of Ramadan fasting on hemoglobin A1C, lipid profile, and body mass index among type 2 diabetic patients in Najran City, Saudi Arabia. OAMJMS 2021;9:318-25. DOI: https://doi.org/10.3889/oamjms.2021.6084
Altoum AEA, Osman AL, Babker AM. Impact of body mass index in malondialdehyde, antioxidant vitamins A, E, C and plasma zinc among type 2 diabetic patients. Kuwait Med J 2019;51:16-20.
Babker AM, Fadlalmula HA, Elggourish AGG, et al. Detection of human platelets antigen polymorphism (HPA-1 and HPA-3) and human factor XIII mutation in Sudanese women with recurrent pregnancy loss. BMC Res Notes 2024;17:66. DOI: https://doi.org/10.1186/s13104-024-06715-w
Jabeen F, Fawwad A, Rizvi HA, Alvi F, 2013. Role of platelet indices, glycemic control and hs-CRP in pathogenesis of vascular complications in type-2 diabetic patients. Pak J Med Sci 2013;29:152-6. DOI: https://doi.org/10.12669/pjms.291.2592
Shilpi K, Potekar RM. A study of platelet indices in type 2 diabetes mellitus patients. Indian J Hematol Blood Transfus 2018;34:115-20. DOI: https://doi.org/10.1007/s12288-017-0825-9
Schneider DJ. Factors contributing to increased platelet reactivity in people with diabetes. Diabetes Care 2009;32:525-7. DOI: https://doi.org/10.2337/dc08-1865
Kodiatte TA, Manikyam UK, Rao SB, et al. Mean platelet volume in type 2 diabetes mellitus. J Lab Physicians 2012;4:5-9. DOI: https://doi.org/10.4103/0974-2727.98662
Çakırca G, Çelik MM. Relationships between glycemic control and platelet Indices, atherogenic index of plasma and vitamin D in patients with type 2 diabetes. EJCM 2019;7:147-52. DOI: https://doi.org/10.32596/ejcm.galenos.2019.08.047
Al Mansoori R, Ismail M, Kandakurti PK, et al. Correlation of haematological parameters and glycated hemoglobin to vitamin D level in type II diabetes mellitus patients attend Thumbay hospital, Ajman, UAE. Biomed Pharmacol J 2023;16:1121-31. DOI: https://doi.org/10.13005/bpj/2692
Boye KS, Thieu VT, Lage MJ, et al. The association between sustained HbA1c control and long-term complications among individuals with type 2 diabetes: a retrospective study. Adv Ther 2022;39:2208-21. DOI: https://doi.org/10.1007/s12325-022-02106-4
Abbas AM, Shalabi MG, Elsiddig SA, et al. Evaluation of angiogenesis by using CD105 and CD34 in Sudanese breast cancer patients. Pak J Biol Sci 2021;24:1144-51. DOI: https://doi.org/10.3923/pjbs.2021.1144.1151
Babker AM, Gameel FE. Molecular characterization of prothrombin G20210A gene mutations in pregnant Sudanese women with spontaneous recurrent abortions. Rawal Med J 2015;40:207-9.
Babker AM, Gameel FE. Methylenetetrahydrofolate Reductase C677T Polymorphism in Sudanese Women with Recurrent Spontaneous Abortions. Kuwait Med J 2016;48:100-4.
Sun B, Gao Y, He F, et al. Association of visit-to-visit HbA1c variability with cardiovascular diseases in type 2 diabetes within or outside the target range of HbA1c. Front Public Health 2022;10:1052485. DOI: https://doi.org/10.3389/fpubh.2022.1052485
Zeitler P, El Ghormli L, Arslanian S, et al. Deterioration of glycemic control in youth-onset type 2 diabetes: what are the early and late predictors? J Clin Endocrinol Metab 2022;107:e3384-94. DOI: https://doi.org/10.1210/clinem/dgac254
Pal R, Bhadada SK. Glycemic control in youth-onset type 2 diabetes: predicting tomorrow based on lessons learnt from TODAY. J Clin Endocrinol Metab 2022;107:e4252-3. DOI: https://doi.org/10.1210/clinem/dgac338
Zeitler P, Hirst K, Copeland KC, et al. HbA1c after a short period of monotherapy with metformin identifies durable glycemic control among adolescents with type 2 diabetes. Diabetes Care 2015;38:2285-92. DOI: https://doi.org/10.2337/dc15-0848
Khandekar MM, Khurana AS, Deshmukh SD, et al. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol 2006;59:146-9. DOI: https://doi.org/10.1136/jcp.2004.025387
Sangapur SM, R S D, Sharanabasappa, Meena B. Platelet indices and their correlation with HbA1c and association with microvascular complications in type-2 diabetes mellitus. Int J Res Med Sci 2023;11:1594-9. DOI: https://doi.org/10.18203/2320-6012.ijrms20231321
Taderegew MM, Woldeamanuel GG, Emeria MS, et al. Platelet indices and its association with microvascular complications among type 2 diabetes mellitus patients in northeast Ethiopia: a Cross-sectional study. Diabetes Metab Syndr Obes 2021;14:865-74. DOI: https://doi.org/10.2147/DMSO.S300460
Papanas N, Symeonidis G, Maltezos E, et ak. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004;15:475-8. DOI: https://doi.org/10.1080/0953710042000267707
Kaplan ZS, Jackson SP. The role of platelets in atherothrombosis. Hematology Am Soc Hematol Educ Progam 2011;2011:51-61. DOI: https://doi.org/10.1182/asheducation-2011.1.51
de la Guía-Galipienso F, Martínez-Ferran M, Vallecillo N, et al. Vitamin D and cardiovascular health. Clin Nutr 2021;40:2946-57. DOI: https://doi.org/10.1016/j.clnu.2020.12.025
Gverović Antunica A, Znaor L, Ivanković M, et al, Vitamin D and diabetic retinopathy. Int J Mol Sci 2023;24:12014. DOI: https://doi.org/10.3390/ijms241512014
Farahmand MA, Daneshzad E, Fung TT, et al. What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails. BMC Endocr Disord 2023;23:15. DOI: https://doi.org/10.1186/s12902-022-01209-x
Nasr MH, Hassan BAR, Othman N, et al. Prevalence of vitamin D deficiency between type 2 diabetes mellitus patients and non-diabetics in the Arab Gulf. Diabetes Metab Syndr Obes 2022;15:647-57. DOI: https://doi.org/10.2147/DMSO.S350626
Hong SH, Kim YB, Choi HS, et al. Association of vitamin D deficiency with diabetic nephropathy. Endocrinol Metab 2021;36:106-13. DOI: https://doi.org/10.3803/EnM.2020.826
Cumhur Cure M, Cure E, Yuce S, et al. Mean platelet volume and vitamin D level. Ann Lab Med 2014;34:98-103. DOI: https://doi.org/10.3343/alm.2014.34.2.98

How to Cite

Ahmed Obaid Al Ali, M., Abdelsamea Mohamedahmed, K., & Babker, A. M. (2025). Role of platelet indices and vitamin D in forecasting deterioration of glycemic control and vascular complications in type 2 diabetes. Italian Journal of Medicine, 19(1). https://doi.org/10.4081/itjm.2025.1875
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