https://doi.org/10.4081/itjm.2024.1820

Incidence and clinicopathological characteristics of breast cancer patients from a single center study

Vol. 18 No. 4 (2024)
Published: 29 October 2024
Breast cancer, body mass index, obesity, Jeddah
Abstract Views: 89
PDF: 23
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Alaa Banjar
asbanjar@kau.edu.sa
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah; Center of Innovation in Personalized Medicine (CIPM), King Abdulaziz University, Jeddah, Saudi Arabia.

Chronic diseases may be associated with adverse clinical characteristics of breast cancer outcomes. This study determined the descriptive association of some chronic diseases and clinicopathological characteristics of breast cancer patients in women diagnosed in a single center in Jeddah, KSA. Retrospective data of 196 patients diagnosed with breast cancer (from 2015-2021) was analyzed. Demographics, patients’ health conditions, and tumor properties were investigated. Most women diagnosed with breast cancer were 40-69 years of age. Women with a body mass index (BMI) classification of overweight/obese were extremely significantly more than those who were classified as lean. The tumors reported show that a significant number of samples (87.0%) had tumors between T1 and T2. Significantly more tumors (61.0%) were of grade V, and ~81.0% were histopathologically classified as invasive ductal carcinoma. A significant majority of breast cancers in this population were human epidermal growth factor receptor 2 negative (70%), progesterone receptor positive (58%), and non-triple negative (~93%). In these patients, a BMI classification of overweight/obese is possibly associated with breast cancer. Awareness and knowledge about the correlation of breast cancer with obesity may help to reduce or delay its presence.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

PlumX Metrics

PlumX Metrics  provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Lei S, Zheng R, Zhang S, et al. Global patterns of breast cancer incidence and mortality: a population-based cancer registry data analysis from 2000 to 2020. Cancer Commun 2021;41:1183-94. DOI: https://doi.org/10.1002/cac2.12207
Saudi Health Council National Cancer Center Saudi Cancer Registry: Cancer Incidence Report In Kingdom of Saudi Arabia 2018. Saudi Health Council National Cancer Center Saudi Cancer Registry; 2022. Available from: https://shc.gov.sa/Arabic/NCC/Activities/AnnualReports/2018.pdf.
García-Closas M, Brinton LA, Lissowska J, et al. Established breast cancer risk factors by clinically important tumour characteristics. Br J Cancer 2006;95:123-9. DOI: https://doi.org/10.1038/sj.bjc.6603207
Liu L, Hao X, Song Z, et al. Correlation between family history and characteristics of breast cancer. Sci Rep 2021;11:6360. DOI: https://doi.org/10.1038/s41598-021-85899-8
Davies NJ, Batehup L, Thomas R. The role of diet and physical activity in breast, colorectal, and prostate cancer survivorship: a review of the literature. Br J Cancer 2011;105:S52-73. DOI: https://doi.org/10.1038/bjc.2011.423
Cleveland RJ, Eng SM, Abrahamson PE, et al. Weight gain prior to diagnosis and survival from breast cancer. Cancer Epidemiol Biomark Prev 2007;16:1803-11. DOI: https://doi.org/10.1158/1055-9965.EPI-06-0889
Maiti B, Kundranda MN, Spiro TP, Daw HA. The association of metabolic syndrome with triple-negative breast cancer. Breast Cancer Res Treat 2010;121:479-83. DOI: https://doi.org/10.1007/s10549-009-0591-y
Carmichael AR. Obesity as a risk factor for development and poor prognosis of breast cancer. BJOG 2006;113:1160-6. DOI: https://doi.org/10.1111/j.1471-0528.2006.01021.x
Suzuki R, Rylander-Rudqvist T, Ye W, et al. Body weight and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status among Swedish women: a prospective cohort study. Int J Cancer 2006;119:1683-9. DOI: https://doi.org/10.1002/ijc.22034
Ahn J, Schatzkin A, Lacey JV, et al. Adiposity, adult weight change, and postmenopausal breast cancer risk. Arch Intern Med 2007;167:2091-102. DOI: https://doi.org/10.1001/archinte.167.19.2091
Korsching E, Packeisen J, Agelopoulos K, et al. Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis. Lab Investig 2002;82:1525-33. DOI: https://doi.org/10.1097/01.LAB.0000038508.86221.B3
Yang XR, Sherman ME, Rimm DL, et al. Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomark Prev 2007:16:439-43. DOI: https://doi.org/10.1158/1055-9965.EPI-06-0806
Weigel MT, Dowsett M. Current and emerging biomarkers in breast cancer: prognosis and prediction. Endocr Relat Cancer 2010;17:R245-62. DOI: https://doi.org/10.1677/ERC-10-0136
Alsolami FJ, Azzeh FS, Ghafouri KJ, et al. Determinants of breast cancer in Saudi women from Makkah region: a case-control study (breast cancer risk factors among Saudi women). BMC Public Health 2019;19:1554. DOI: https://doi.org/10.1186/s12889-019-7942-3
Babiker S, Nasir O, Alotaibi SH, et al. Prospective breast cancer risk factors prediction in Saudi women. Saudi J Biol Sci 2020;27:1624-31. DOI: https://doi.org/10.1016/j.sjbs.2020.02.012
Bendardaf R, Saheb Sharif-Askari F, Saheb Sharif-Askari N, et al. Incidence and clinicopathological features of breast cancer in the northern Emirates: Experience from Sharjah breast care center. Int J Womens Health 2020;12:893-9. DOI: https://doi.org/10.2147/IJWH.S266335
Lara-Medina F, Pérez-Sánchez V, Saavedra-Pérez D, et al. Triple-negative breast cancer in Hispanic patients: High prevalence, poor prognosis, and association with menopausal status, body mass index, and parity. Cancer 2011;117:3658-69. DOI: https://doi.org/10.1002/cncr.25961
Alshamsan B, Suleman K, Agha N, et al. Association between obesity and clinicopathological profile of patients with newly diagnosed non-metastatic breast cancer in Saudi Arabia. Int J Womens Health 2022;14:373-84. DOI: https://doi.org/10.2147/IJWH.S343558
Hossain FM, Danos DM, Fu Q, et al. Association of obesity and diabetes with the incidence of breast cancer in Louisiana. Am J Prev Med 2022;63:S83-92. DOI: https://doi.org/10.1016/j.amepre.2022.02.017
Buono G, Crispo A, Giuliano M, et al. Combined effect of obesity and diabetes on early breast cancer outcome: a prospective observational study. Oncotarget 2017;8:115709-17. DOI: https://doi.org/10.18632/oncotarget.22977
Eketunde AO. Diabetes as a Risk factor for breast cancer. Cureus 2020;12:e8010. DOI: https://doi.org/10.7759/cureus.8010
Stead LA, Lash TL, Sobieraj JE, et al. Triple-negative breast cancers are increased in black women regardless of age or body mass index. Breast Cancer Res 2009;11:R18. DOI: https://doi.org/10.1186/bcr2242
Zagami P, Carey LA. Triple negative breast cancer: pitfalls and progress. NPJ Breast Cancer 2022;8:95. DOI: https://doi.org/10.1038/s41523-022-00468-0
Bauer KR, Brown M, Cress RD, et al. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry. Cancer 2007;109:1721-8. DOI: https://doi.org/10.1002/cncr.22618
Zekri J, Saadeddin A, Alharbi H. Frequency and clinical characteristics of HER2 over-expressed breast cancer in Saudi Arabia: a retrospective study. BMC Womens Health 2021;21:10. DOI: https://doi.org/10.1186/s12905-020-01159-3
Alabdulkarim B, Hassanain M, Bokhari A, et al. Age distribution and outcomes in patients undergoing breast cancer resection in Saudi Arabia. A single-institute study. Saudi Med J 2018;39:464-9. DOI: https://doi.org/10.15537/smj.2018.5.21993

How to Cite

Banjar, A. (2024). Incidence and clinicopathological characteristics of breast cancer patients from a single center study. Italian Journal of Medicine, 18(4). https://doi.org/10.4081/itjm.2024.1820
Copyright (c) 2024 the Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.