Micronutrition and diabetes: a new view at prevention and treatment

Submitted: 17 April 2024
Accepted: 7 May 2024
Published: 24 May 2024
Abstract Views: 333
PDF: 211
HTML: 39
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Worldwide, millions of people suffer from diabetes. Our study aimed to describe the sample’s weight status and the effects of providing individualized micronutrient prescriptions and nutritional counseling to individuals with diabetes. Of the 46 patients (26 women and 20 men) enrolled in this study between 2014 and 2021, 41% had insulin-resistant diabetes and were over the age of 18. In compliance with the World Health Organization guidelines, anthropometric measurements were taken. The impedencemeter was used to measure the visceral fat. Diabetes affected 41% of the patients, with women making up the majority (74%). An impedencemeter’s average measurement of 6 for visceral fat loss was encouraging, and a glycated hemoglobin analysis of diabetics revealed an average loss of 1.6%. A good sign for lowering the therapeutic load is that 16% of diabetic patients were able to stop taking any medication at all, and 79% of patients were able to reduce their dosage. This study served as a strong foundation for the creation of customized nutritional management programs in Morocco to enhance the metabolic health of patients who are obese and insulin-resistant.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

PlumX Metrics

PlumX Metrics  provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

Citations

Rabot S, Rafter J, Rijkers GT, et al. Guidance for substantiating the evidence for beneficial effects of probiotics: impact of probiotics on digestive system metabolism. J Nutr 2010;140:677S-89S. DOI: https://doi.org/10.3945/jn.109.113738
Haller D, Antoine JM, Bengmark S, et al. Guidance for substantiating the evidence for beneficial effects of probiotics: probiotics in chronic inflammatory bowel disease and the functional disorder irritable bowel syndrome [published correction appears in J Nutr 2010;140:1189]. J Nutr 2010;140:690S-7S. DOI: https://doi.org/10.3945/jn.109.113746
Ohland CL, Macnaughton WK. Probiotic bacteria and intestinal epithelial barrier function. Am J Physiol Gastrointest Liver Physiol 2010;298:G807-G19. DOI: https://doi.org/10.1152/ajpgi.00243.2009
Wurtman RJ, Wurtman JJ. Brain serotonin, carbohydrate-craving, obesity and depression. In: Recent Advances in Tryptophan Research: Tryptophan and Serotonin Pathways. Springer 1996;35-42. DOI: https://doi.org/10.1007/978-1-4613-0381-7_4
Head KA, Kelly GS. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev 2009;14:114-40.
Larrieu S, Letenneur L, Helmer C, et al. Nutritional factors and risk of incident dementia in the PAQUID longitudinal cohort. J Nutr Health Aging 2004;8:150-4.
Lecerf JM, Desmettre T. Nutrition et dégénérescence maculaire liée à l’âge [Nutrition and age-related macular degeneration]. J Fr Ophtalmol 2010;33:749-57. DOI: https://doi.org/10.1016/j.jfo.2010.09.011
Gillette-Guyonnet S, Van Kan GA, Andrieu S, et al. IANA task force on nutrition and cognitive decline with aging. J Nutr Health Aging 2007;11:132.
Riché MD. Micronutrition, santé et performance: Comprendre ce qu’est vraiment la micronutrition. De Boeck Supérieur, Belgium; 2008.
Chahoud G, Aude YW, Mehta JL. Dietary recommendations in the prevention and treatment of coronary heart disease: do we have the ideal diet yet? Am J Cardiol 2004;94(:1260-7. DOI: https://doi.org/10.1016/j.amjcard.2004.07.109
Suksomboon N, Poolsup N, Sinprasert S. Effects of vitamin E supplementation on glycaemic control in type 2 diabetes: systematic review of randomized controlled trials. J Clin Pharm Ther 2011;36:53-63. DOI: https://doi.org/10.1111/j.1365-2710.2009.01154.x
Cavalier E, Delanaye P, Souberbielle JC, et al. Vitamin D and type 2 diabetes mellitus: where do we stand? Diabetes Metab 2011;37:265-72. DOI: https://doi.org/10.1016/j.diabet.2011.01.001
Dubey P, Thakur V, Chattopadhyay M. Role of minerals and trace elements in diabetes and insulin resistance. Nutrients 2020;12:1864. DOI: https://doi.org/10.3390/nu12061864
Guerrero-Romero F, Rodríguez-Morán M. [Oral magnesium supplementation: an adjuvant alternative to facing the worldwide challenge of type 2 diabetes?]. Cir Cir 2014; 82:282-9.
Guerrero-Romero F, Simental-Mendía LE, Hernández-Ronquillo G, Rodriguez-Morán M. Oral magnesium supplementation improves glycaemic status in subjects with prediabetes and hypomagnesaemia: a double-blind placebo-controlled randomized trial. Diabetes Metab 2015;41:202-07. DOI: https://doi.org/10.1016/j.diabet.2015.03.010
Yokota K, Kato M, Lister F, et al. Clinical efficacy of magnesium supplementation in patients with type 2 diabetes. J Am Coll Nutr 2004;23:506S-09S. DOI: https://doi.org/10.1080/07315724.2004.10719390
Rodríguez-Morán M, Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care 2003;26:1147-52. DOI: https://doi.org/10.2337/diacare.26.4.1147
Guerrero-Romero F, Tamez-Perez HE, González-González G, et al. Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab 2004;30:253-58. DOI: https://doi.org/10.1016/S1262-3636(07)70116-7
San Mauro-Martin I, Ruiz-León AM, Camina-Martín MA, et al. [Chromium supplementation in patients with type 2 diabetes and high risk of type 2 diabetes: a meta-analysis of randomized controlled trials]. Nutr Hosp 2016;33:27.
Ekmekcioglu C, Prohaska C, Pomazal K, et al. Concentrations of seven trace elements in different hematological matrices in patients with type 2 diabetes as compared to healthy controls. Biol Trace Elem Res 2001;79:205-19. DOI: https://doi.org/10.1385/BTER:79:3:205
Davies S, McLaren Howard J, Hunnisett A, Howard M. Age-related decreases in chromium levels in 51,665 hair, sweat, and serum samples from 40,872 patients--implications for the prevention of cardiovascular disease and type II diabetes mellitus. Metabolism1997;46:469-73. DOI: https://doi.org/10.1016/S0026-0495(97)90179-7
Docherty JP, Sack DA, Roffman M, et al. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving. J Psychiatr Pract 2005;11:302-14. DOI: https://doi.org/10.1097/00131746-200509000-00004
Porasuphatana S, Suddee S, Nartnampong A, et al. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study. Asia Pac J Clin Nutr 2012;21:12-21.
McIlduff CE, Rutkove SB. Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy. Ther Clin Risk Manag 2011;7:377-85. DOI: https://doi.org/10.2147/TCRM.S11325
Mingrone G. Carnitine in type 2 diabetes. Ann N Y Acad Sci 2004:99-107.
Vidal-Casariego A, Burgos-Peláez R, Martínez-Faedo C, et al. Metabolic effects of L-carnitine on type 2 diabetes mellitus: systematic review and meta-analysis. Exp Clin Endocrinol Diabetes 2013;121:234-38. DOI: https://doi.org/10.1055/s-0033-1333688
Sima AA, Calvani M, Mehra M, Amato A, Acetyl-L-Carnitine Study Group. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. Diabetes Care 2005;28:89-94. DOI: https://doi.org/10.2337/diacare.28.1.89
Turpeinen AK, Kuikka JT, Vanninen E, et al. Long-term effect of acetyl-L-carnitine on myocardial 123I-MIBG uptake in patients with diabetes. Clin Auton Res 2000;10:13-6. DOI: https://doi.org/10.1007/BF02291384
Benedetti L, Didier C. Maigrir avec la micronutrition, First, 2010.
Janssen I, Katzmarzyk PT, Ross R. Body mass index, waist circumference, and health risk: evidence in support of current National Institutes of Health guidelines. Arch Intern Med 2002;162:2074-9. DOI: https://doi.org/10.1001/archinte.162.18.2074
Frayn KN. Visceral fat and insulin resistance--causative or correlative? Br J Nutr 2000;83:S71-7. DOI: https://doi.org/10.1017/S0007114500000982
Mauro-Martin S, Ruiz-León AM, Camina-Martín MA, et al. Chromium supplementation in patients with type 2 diabetes and high risk of type 2 diabetes: a meta-analysis of randomized controlled trials. Nutr Hosp 2016;33:27. DOI: https://doi.org/10.20960/nh.27
Porasuphatana S, Suddee S, Nartnampong A, et al. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alphalipoic acid: a randomized double-blinded placebocontrolled study. Asia Pac J Clin Nutr 2012;21;12-21.
Mingrone G. Carnitine in type 2 diabetes. Ann N Y Acad Sci 2004;1033:99-107. DOI: https://doi.org/10.1196/annals.1320.009
Garvey WT, Mechanick JI, Brett EM, et al. Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines. American association of clinical endocrinologists and American college of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract 2016;3:1-203. DOI: https://doi.org/10.4158/EP161365.GL
Yahia-Berrouiguet A, Benyoucef M, Meguenni K et al. Enquęte sur la prévalence des facteurs de risque de maladies cardiovasculaires ā Tlemcen (Algérie). Médecine des maladies Métaboliques 2011;5:42-8. DOI: https://doi.org/10.1016/S1957-2557(11)70071-2
Gómez-Ambrosi J, Catalán V. Prevalencia de diabesidad en España: depende de cómo se defina la obesidad. An Sist Sanit Navar 2022.
Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract 2019;157:107843. DOI: https://doi.org/10.1016/j.diabres.2019.107843
Standl E, Khunti K, Hansen TB, Schnell O. The global epidemics of diabetes in the 21st century: Current situation and perspectives. Eur J Prev Cardiol 2019;26:7-14. DOI: https://doi.org/10.1177/2047487319881021
Sun H, Saeedi P, Karuranga S, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 [published correction appears in Diabetes Res Clin Pract 2023;204:110945]. Diabetes Res Clin Pract 2022;183:109119. DOI: https://doi.org/10.1016/j.diabres.2021.109119
Wang L, Gao P, Zhang M, et al. Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA 2017;317:2515-23. DOI: https://doi.org/10.1001/jama.2017.7596
Hansen M, Lund MT, Jørgensen AL, et al. The effects of diet- and RYGB-induced weight loss on insulin sensitivity in obese patients with and without type 2 diabetes. Acta Diabetol 2016;53:423-32. DOI: https://doi.org/10.1007/s00592-015-0812-2

How to Cite

Ouali, K., Ibrahmi, B. A., Bouchefra, S., & Bour, A. (2024). Micronutrition and diabetes: a new view at prevention and treatment. Italian Journal of Medicine, 18(2). https://doi.org/10.4081/itjm.2024.1728