https://doi.org/10.4081/itjm.2024.1713

Acquired hemophilia A in a case of purple urine bag syndrome

Vol. 18 No. 2 (2024)
Submitted: 5 March 2024
Accepted: 19 April 2024
Published: 16 May 2024
Acquired hemophilia A, urinary tract infection, purple urine bag syndrome
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Authors

Vittoria Gammaldi
gammaldivittoria@gmail.com
Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Anna Guida
Congenital Hemorrhagic and Thrombotic Diseases Center, San Giovanni di Dio e Ruggi d’Aragona Hospital, Salerno, Italy.
Carolina Bologna
Department of Internal Medicine, “Ospedale del Mare”, ASL Napoli 1 Centro, Naples, Italy.
Antonietta De Sena
Department of Internal Medicine, “Ospedale del Mare”, ASL Napoli 1 Centro, Naples, Italy.
Marina Lugarà
Department of Internal Medicine, “Ospedale del Mare”, ASL Napoli 1 Centro, Naples, Italy.
Claudio De Luca
Department of Internal Medicine, “Ospedale del Mare”, ASL Napoli 1 Centro, Naples, Italy.
Fabio Granato Corigliano
Department of Internal Medicine, “Ospedale del Mare”, ASL Napoli 1 Centro, Naples, Italy.
Mariavittoria Guerra
Department of Internal Medicine, “Ospedale del Mare”, ASL Napoli 1 Centro, Naples, Italy.
Gabriella Oliva
Department of Internal Medicine, “Ospedale del Mare”, ASL Napoli 1 Centro, Naples, Italy.
Luca Mocerino
Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Aquilino Flavio Zarrella
Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Maria Gabriella Coppola
Division of Emergency Medicine, AORN “San Pio” Benevento, Italy.
Vincenzo Nuzzo
Department of Internal Medicine, “Ospedale del Mare”, ASL Napoli 1 Centro, Naples, Italy.
Paolo Tirelli
Department of Internal Medicine, “Ospedale del Mare”, ASL Napoli 1 Centro, Naples, Italy.
Pasquale Madonna
Department of Internal Medicine, “Ospedale del Mare”, ASL Napoli 1 Centro, Naples, Italy.

The rare hemorrhagic disorder known as acquired hemophilia A (AHA) is brought on by the spontaneous development of autoantibodies against coagulation factor VIII (FVIII). It may be secondary to autoimmune diseases or cancers, or it may be idiopathic. Less than 10% of cases may have an infection as a secondary cause. We present the case of a 90-year-old anemic woman who was admitted to the hospital. She contracted a urinary tract infection (UTI) while in the hospital, and her urine took on a distinct purple hue. She had poor hemorrhagic manifestations and a prolonged partial thromboplastin time. After ruling out autoimmune and neoplastic causes, we diagnosed AHA as a result of a UTI caused by Enterococcus faecalis.

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How to Cite

Gammaldi, V., Guida, A., Bologna, C., De Sena, A., Lugarà, M., De Luca, C., Granato Corigliano, F., Guerra, M., Oliva, G., Mocerino, L., Zarrella, A. F., Coppola, M. G., Nuzzo, V., Tirelli, P., & Madonna, P. (2024). Acquired hemophilia A in a case of purple urine bag syndrome. Italian Journal of Medicine, 18(2). https://doi.org/10.4081/itjm.2024.1713
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