https://doi.org/10.4081/itjm.2024.1707
Clinical factors affecting short- and long-term mortality in older patients with COVID-19: a retrospective cohort study
Published: 8 March 2024
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The majority of fatal cases of SARS-CoV-2 was concentrated among older patients. We aimed at assessing risk factors contributing to mortality in this population. A retrospective study including 584 COVID-19 patients aged ≥80 years hospitalized between October 10th 2020 to May 4th 2021 at Ospedale di Circolo (Varese, Italy) and Ospedale Galmarini (Tradate, Italy) was conducted. Evaluation of risk factors associated with in-hospital mortality was the primary endpoint. 509 patients were considered. Median age was 86 [82-89] years. Almost half of the patients (n=241) suffered from ≥3 comorbidities. Overall in-hospital mortality was 39.7% (n=202). Age, chronic kidney disease (CKD), peripheral oxygen saturation at admission, and high-flow oxygen during hospital stay independently predicted in-hospital mortality. Overall mortality at 6 months was 57.8% (n=294) and increased with increasing age and number of comorbidities (P<0.05). Age, CKD, and dementia independently predicted 6-month mortality. Age and comorbidities predicted short- and long-term mortality in older patients (≥80 years). Stratification of patients according to age and comorbidities might provide critical information for a better management of elderly patients.
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How to Cite
Pennella, B., Rotunno, F., Mercuri, M., Guerci, M., Molteni, M., Biancucci, M., Berton, C., Troian, F., Tripodi, P. M., Gilio, A., Milano, A., Dalla Gasperina, D., Dentali, F., Bonaventura, A., & Maresca, A. M. (2024). Clinical factors affecting short- and long-term mortality in older patients with COVID-19: a retrospective cohort study. Italian Journal of Medicine, 18(1). https://doi.org/10.4081/itjm.2024.1707
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