https://doi.org/10.4081/itjm.2024.1694

Semaglutide and kidney function: friends or enemies?

Vol. 18 No. 1 (2024)
Published: 5 February 2024
Semaglutide, glucagon-like peptide-1 receptor agonist, type 2 diabetes, acute kidney injury, obesity
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Authors

Federica Giofrè
Internal Medicine Unit, Department of Medical and Surgical Sciences, “Magna Graecia” University of Catanzaro, Italy.
Vincenzo Trapanese
vincenzo.trapanese@studenti.unicz.it
https://orcid.org/0009-0002-3432-804X
Internal Medicine Unit, Department of Medical and Surgical Sciences, “Magna Graecia” University of Catanzaro, Italy.
Maria Resilde Natale
Internal Medicine Unit, Department of Medical and Surgical Sciences, “Magna Graecia” University of Catanzaro, Italy.
Clara Vatalaro
Internal Medicine Unit, Department of Medical and Surgical Sciences, “Magna Graecia” University of Catanzaro, Italy.
Francesca Cosentino
Internal Medicine Unit, Department of Medical and Surgical Sciences, “Magna Graecia” University of Catanzaro, Italy.
Melania Melina
Internal Medicine Unit, Department of Medical and Surgical Sciences, “Magna Graecia” University of Catanzaro, Italy.
Maria Chiara Pelle
Internal Medicine Unit, Department of Medical and Surgical Sciences, “Magna Graecia” University of Catanzaro, Italy.
Nazareno Carullo
Renal Unit, “Renato Dulbecco” Hospital of Catanzaro, Italy.
Maria Capria
Renal Unit, “Renato Dulbecco” Hospital of Catanzaro, Italy.
Franco Arturi
Internal Medicine Unit, Department of Medical and Surgical Sciences, “Magna Graecia” University of Catanzaro; Research Centre for the Prevention and Treatment of Metabolic Diseases (CR METDIS), “Magna Graecia” University of Catanzaro, Italy.

Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RAs) approved for the treatment of type 2 diabetes mellitus (T2DM) and chronic weight management in obesity. GLP-1RAs are being investigated to slow the decline of kidney function in type 2 diabetics with chronic kidney disease. These agents prevent renal complications and have proven beneficial effects on cardiac outcomes. We describe a rare case of semaglutide-induced acute kidney injury (AKI) in a young woman with obesity, T2DM, hypertensive cardiomyopathy, and no pre-existing chronic kidney disease (CKD). This case is relevant as GLP1-RAs is used frequently in patients with and without kidney disease. Currently, only 3 cases of AKI ascribed to semaglutide of which only 1 without CKD have been described. Only in this case, kidney function improves after semaglutide discontinuation. However, because GLP1-RAs will be prescribed more and more frequently, we sought to highlight this possible, serious adverse effect of semaglutide.

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How to Cite

Giofrè, F., Trapanese, V., Natale, M. R., Vatalaro, C., Cosentino, F., Melina, M., Pelle, M. C., Carullo, N., Capria, M., & Arturi, F. (2024). Semaglutide and kidney function: friends or enemies?. Italian Journal of Medicine, 18(1). https://doi.org/10.4081/itjm.2024.1694
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