https://doi.org/10.4081/itjm.2023.1650

STAT3 eye-opener in COVID-19

Vol. 17 No. 3 (2023)
Published: 28 November 2023
COVID-19, STAT3, IL-6, circulating cells, vitamin D
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Authors

Chiara Mozzini
chiara.mozzini@asst-mantova.it
https://orcid.org/0000-0002-4414-6576
Department of Medicine, ASST Mantova, C. Poma Hospital, Mantova, Italy.
Giuseppe Lucchini
Biostatistic Unit, ASST Mantova, C. Poma Hospital, Mantova, Italy.
Mauro Pagani
Department of Medicine, ASST Mantova, C. Poma Hospital, Mantova, Italy.

Among the elevated inflammatory mediators, blood Interleukin-6 (IL-6) level is highly correlated with COVID-19 mortality and predicts the need for mechanical ventilation. IL-6 is the major activator of signal transducers and activators of transcription-3 (STAT3) during inflammatory responses. The primary objective of the study is to explore STAT3 activation in different subsets of circulating cells derived from 25 COVID-19 patients (patients) admitted to an Internal Medicine department compared to 25 healthy donors (HD). Higher percentages of classical and intermediate monocytes were observed in patients, compared to HD (respectively P<0.01 and P<0.001). The active form of STAT3, phosphorylated STAT3 (pSTAT3) was significantly higher in patients, compared to HD, both in non-classical and in intermediate monocytes (P<0.001). Low-density neutrophils (LDN) count was significantly higher in patients compared to HD (P<0.001). The pSTAT3 was significantly higher in LDN derived from patients (P<0.05). High pSTAT3 was significantly directly related to d-dimer and inversely related to vitamin D levels (P<0.01). This study gives information about STAT3 activation and the possible role of Vitamin D as a tool against COVID-19.

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How to Cite

Mozzini, C., Lucchini, G., & Pagani, M. (2023). STAT3 eye-opener in COVID-19. Italian Journal of Medicine, 17(3). https://doi.org/10.4081/itjm.2023.1650
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