https://doi.org/10.4081/itjm.2023.1639
The mechanism of action of Spirulina as antidiabetic: a narrative review
Submitted: 12 August 2023
Accepted: 15 September 2023
Published: 20 September 2023
Accepted: 15 September 2023
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Spirulina happens to be a special type of blue-green algae that originally emerged 3.5 billion years ago and was used as a source of nutrition. Spirulina gets its name from the filaments’ spiral or helical structure, but its true name is taxonomically Genus Arthrospira which encompasses several species. The most common species are S. fusiformis, S. maxima, and S. platensis. It is rich in various nutrients and chemical components including protein, carbohydrates, lipids, vitamins, minerals, pigments, chlorophyll, and enzymes. Spirulina’s active molecules and rich nutrients make it have several pharmacological activities and uses including antioxidant, anti-inflammatory, immunomodulatory, immune system booster, anticancer, antiviral activity, and neuroprotective properties. It is also utilized as a nutritional supplement and for weight loss. Moreover, several studies confirm that Spirulina improves insulin sensitivity and reduces blood glucose levels in rat models as well as diabetic patients. The reason behind this unique behavior could be credited to the presence of several active components in it, but the action’s fundamental mechanism is still a matter of debate. Several studies have suggested different mechanisms including anti-inflammatory activity, increased insulin sensitivity, inhibition of gluconeogenesis, antioxidant activity, modulating gut microbiota composition, improved glucose homeostasis, and insulin receptor activation. Therefore, it became clear that Spirulina is a mine of active substances used as a nutritional supplement and reduces blood glucose levels or used in conjunction with other treatments to tackle type 2 diabetes. Further exploration is required to fully explain its effects on human physiology and determine optimal dosages for treatment.
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Citations
Kumar R, Itumalla R, Perera B, et al. Patient knowledge about diabetes: Illness symptoms, complications, and preventive personal lifestyle factors. Health Psychol Res 2022;10:37520.
DOI: https://doi.org/10.52965/001c.37520
ElSayed NA, Aleppo G, Aroda VR, et al. 2. Classification and diagnosis of diabetes: standards of care in diabetes-2023. Diabetes care 2023;46:S19-40.
DOI: https://doi.org/10.2337/dc23-S002
Adu MD, Malabu UH, Malau-Aduli AEO, Malau-Aduli BS. Enablers and barriers to effective diabetes self-management: A multi-national investigation. PLoS One 2019;14:e0217771.
DOI: https://doi.org/10.1371/journal.pone.0217771
Williams DM, Jones H, Stephens JW. Personalized Type 2 Diabetes Management: An Update on Recent Advances and Recommendations. Diabetes Metab Syndr Obes 2022;15:281-295.
DOI: https://doi.org/10.2147/DMSO.S331654
Finamore A, Palmery M, Bensehaila S, Peluso I. Antioxidant, Immunomodulating, and Microbial-Modulating Activities of the Sustainable and Ecofriendly Spirulina. Oxid Med Cell Longev 2017;2017:3247528.
DOI: https://doi.org/10.1155/2017/3247528
Asghari A, Fazilati M, Latifi AM, Salavati H, Choopani A. A Review on Antioxidant Properties of Spirulina. J Appl Biotechnol Rep 2016;3:345-51.
Guldas M, Ziyanok-Demirtas S, Sahan Y, et al. Antioxidant and anti-diabetic properties of Spirulina platensis produced in Turkey. Food Sci Technol (Campinas) 2021;41:615-25.
DOI: https://doi.org/10.1590/fst.23920
Sotiroudis TG, Sotiroudis GT. Health aspects of Spirulina (Arthrospira) microalga food supplement. J Serb Chem Soc 2013;78:395-405.
DOI: https://doi.org/10.2298/JSC121020152S
Papapanagiotou G, Gkelis S. Taxonomic revision of commercially used Arthrospira (Cyanobacteria) strains: a polyphasic approach. Eur J Phycol 2019;54:595-608.
DOI: https://doi.org/10.1080/09670262.2019.1624832
Nowicka-Krawczyk P, Mühlsteinová R, Hauer T. Detailed characterization of the Arthrospira type species separating commercially grown taxa into the new genus Limnospira (Cyanobacteria). Sci Rep 2019;9:694.
DOI: https://doi.org/10.1038/s41598-018-36831-0
Park WS, Kim HJ, Li M, et al. Two Classes of Pigments, Carotenoids and C-Phycocyanin, in Spirulina Powder and Their Antioxidant Activities. Molecules 2018;23:2065.
DOI: https://doi.org/10.3390/molecules23082065
Anvar AA, Nowruzi B. Bioactive properties of spirulina: A review. Microb Bioact 2021;4:134-42.
DOI: https://doi.org/10.25163/microbbioacts.412117B0719110521
Andrade LM, Andrade CJ, Dias M, et al. Chlorella and Spirulina microalgae as sources of functional foods, nutraceuticals, and food supplements; an overview. MOJ Food Process Technol 2018;6:45-58.
DOI: https://doi.org/10.15406/mojfpt.2018.06.00144
AlFadhly NKZ, Alhelfi N, Altemimi AB, et al. Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. Molecules 2022;27:5584.
DOI: https://doi.org/10.3390/molecules27175584
Farag MR, Alagawany M, El-Hack ME, Kuldeep D. Nutritional and healthical aspects of Spirulina (Arthrospira) for poultry, animals, and human. Int J Pharmacol 2016; 12:36-51.
DOI: https://doi.org/10.3923/ijp.2016.36.51
Capelli B, Cysewski GR. Potential health benefits of Spirulina microalgae* A review of the existing literature. Nutrafoods 2010;9:19-26.
DOI: https://doi.org/10.1007/BF03223332
Gheda SF, Abo-Shady AM, Abdel-Karim OH, Ismail GA. Antioxidant and Antihyperglycemic Activity of Arthrospira platensis (Spirulina platensis) Methanolic Extract: In vitro and in vivo Study. Egypt J Bot 2021;61:71-93.
Deng R, Chow TJ. Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae Spirulina. Cardiovasc Ther 2010;28:e33-45.
DOI: https://doi.org/10.1111/j.1755-5922.2010.00200.x
Choi WY, Kang DH, Lee HY. Enhancement of immune activation activities of Spirulina maxima grown in deepsea water. Int J Mol Sci 2013;14:12205-21.
DOI: https://doi.org/10.3390/ijms140612205
Trotta T, Porro C, Cianciulli A, Panaro MA. Beneficial effects of Spirulina consumption on brain health. Nutrients 2022;14:676.
DOI: https://doi.org/10.3390/nu14030676
Tamtaji OR, Heidari-soureshjani R, Asemi Z, Kouchaki E. The effects of Spirulina intake on clinical and metabolic parameters in Alzheimer’s disease: A randomized, double-blind, controlled trial. Phytother Res 2023. Available from: https://doi.org/10.1002/ptr.7791
DOI: https://doi.org/10.1002/ptr.7791
Mazokopakis EE, Starakis IK, Papadomanolaki MG, et al. The hypolipidaemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population: a prospective study. J Sci Food Agric 2014;94:432-7.
DOI: https://doi.org/10.1002/jsfa.6261
Kajimoto Y, Kaneto H. Role of oxidative stress in pancreatic beta-cell dysfunction. Ann NY Acad Sci 2004;1011:168-76.
DOI: https://doi.org/10.1196/annals.1293.017
Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci 2008;4:89-96.
Li Y. The Bioactivities of Phycocyanobilin from Spirulina. J Immunol Res 2022;2022:4008991.
DOI: https://doi.org/10.1155/2022/4008991
Stoyneva-Gärtner M, Uzunov B, Gärtner G. Enigmatic microalgae from aeroterrestrial and extreme habitats in cosmetics: The potential of the untapped natural sources. Cosmetics 2020;7:27.
DOI: https://doi.org/10.3390/cosmetics7020027
Kumar A, Ramamoorthy D, Verma DK, et al. Antioxidant and phytonutrient activities of Spirulina platensis. Energy Nexus 2022;6:100070.
DOI: https://doi.org/10.1016/j.nexus.2022.100070
Abraham RE, Alghazwi M, Liang Q, Zhang W. Advances on marine-derived natural radioprotection compounds: historic development and future perspective. Mar Life Sci Technol 2021;3:474-87.
DOI: https://doi.org/10.1007/s42995-021-00095-x
Uppin V, Dharmesh SM. Polysaccharide from Spirulina platensis Evokes Antitumor Activity in Gastric Cancer Cells via Modulation of Galectin-3 and Exhibited Cyto/DNA Protection: Structure–Function Study. J Agric Food Chem 2022;70:7058-69.
DOI: https://doi.org/10.1021/acs.jafc.2c00176
Reynolds D, Huesemann M, Edmundson S, et al. Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis. Algal Res 2021;57:102331.
DOI: https://doi.org/10.1016/j.algal.2021.102331
El-Sayed E-S, Hikal M, Abo El-Khair B, et al. Hypoglycemic and Hypolipidemic Effects of Spirulina platensis, Phycocyanin, Phycocyanopeptide and Phycocyanobilin on Male Diabetic Rats. Arab Univ J Agric Sci 2018;26,:1121-34.
DOI: https://doi.org/10.21608/ajs.2018.28365
Abdel-Daim MM, Shaaban Ali M, Madkour FF, Elgendy H. Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat Model. J Pain Res 2020;13:2289-96.
DOI: https://doi.org/10.2147/JPR.S267347
Okechukwu PN, Ekeuku SO, Sharma M, et al. In vivo and in vitro antidiabetic and antioxidant activity of Spirulina. Phcog Mag 2019;15:17-29.
Laela N, Legowo AM, Fulyani F. The effect of kefir-spirulina on glycemic status and antioxidant activity in hyperglycemia rats. Potr S J Food Sci 2021;15:101-10.
DOI: https://doi.org/10.5219/1445
Petrie JR, Guzik TJ, Touyz RM. Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms. Can J Cardiol 2018;34:575-84.
DOI: https://doi.org/10.1016/j.cjca.2017.12.005
Joventino IP, Alves HGR, Neves LC, et al. The Microalga Spirulina platensis Presents Anti-inflammatory Action as well as Hypoglycemic and Hypolipidemic Properties in Diabetic Rats. J Complement Integr Med 2012;9.
DOI: https://doi.org/10.1515/1553-3840.1534
Bocanegra A, Macho-González A, Garcimartín A, et al. Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus. Int J Mol Sci 2021;22:3816.
DOI: https://doi.org/10.3390/ijms22083816
Senthil N, Balu PM, Murugesan K. Antihyperglycemic effect of spirulina, insulin and Morinda citrifolia against streptozotocin induced diabetic rats. Int J Curr Microbiol Appl Sci 2013;2:537-59.
Simon JP, Baskaran UL, Shallauddin KB, et al. Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats. Biotech. 2018;8:129.
DOI: https://doi.org/10.1007/s13205-018-1156-8
Anitha L, Chandralekha K. Effect of supplementation of spirulina on blood glucose, glycosylated hemoglobin and lipid profile of male non-insulin dependent diabetics. Asian J Exp Biol Sci 2010;1:36-46.
Nasirian F, Dadkhah M, Moradi-Kor N, Obeidavi Z. Effects of Spirulina platensis microalgae on antioxidant and anti-inflammatory factors in diabetic rats. Diabetes Metab Syndr Obes 2018;11:375-80.
DOI: https://doi.org/10.2147/DMSO.S172104
Setyaningsih I, Bintang M, Madina N. Potentially antihyperglycemic from biomass and phycocyanin of Spirulina fusiformis voronikhin by in vivo test. Procedia Chem 2015;14:211-5.
DOI: https://doi.org/10.1016/j.proche.2015.03.030
Pandey JP, Tiwari A, Mishra G, Mishra RM. Role of Spirulina maxima in the Control of Blood Glucose Levels and Body Weight in Streptozotocin induced Diabetic Male Wistar rats. J Algal Biomass Utln 2011;2:35-7.
Hannan JMA, Ansari P, Azam S, et al. Effects of Spirulina platensis on insulin secretion, dipeptidyl peptidase IV activity and both carbohydrate digestion and absorption indicate potential as an adjunctive therapy for diabetes. Br J Nutr 2020;124:1021-34.
DOI: https://doi.org/10.1017/S0007114520002111
Hatami E, Ghalishourani SS, Najafgholizadeh A, et al. The effect of spirulina on type 2 diabetes: a systematic review and meta-analysis. J Diabetes Metab Disord 2021;20:883-92.
DOI: https://doi.org/10.1007/s40200-021-00760-z
Rodríguez IA, Serafini M, Alves IA, et al. Natural Products as Outstanding Alternatives in Diabetes Mellitus: A Patent Review. Pharmaceutics 2022;15:85.
DOI: https://doi.org/10.3390/pharmaceutics15010085
Hozayen WG, Mahmoud AM, Soliman HA, Mostafa SR. Spirulina versicolor improves insulin sensitivity and attenuates hyperglycemia-mediated oxidative stress in fructose-fed rats. J Intercult Ethnopharmacol 2016;5:57-64.
DOI: https://doi.org/10.5455/jice.20151230055930
Ekeuku SO, Chong PN, Chan HK, et al. Spirulina supplementation improves bone structural strength and stiffness in streptozocin-induced diabetic rats. J Tradit Complement Med 2021;12:225-34.
DOI: https://doi.org/10.1016/j.jtcme.2021.07.010
Feng W, Liu J, Cheng H, et al. Dietary compounds in modulation of gut microbiota-derived metabolites. Front Nutr 2022;9:939571.
DOI: https://doi.org/10.3389/fnut.2022.939571
How to Cite
El-Sakhawy, M. A., Iqbal, M. Z., Gabr, G. A., Alqasem, A. A., Ateya, A. A. E.-S., Ahmed, F. A., El-Hashash, S. A., Ibrahim, H. S., & Abu El-Ghiet, U. M. (2023). The mechanism of action of Spirulina as antidiabetic: a narrative review. Italian Journal of Medicine, 17(2). https://doi.org/10.4081/itjm.2023.1639
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