MRSA bacteremia and new-onset aortic and mitral regurgitation: a pernicious and tricky association

Published: 19 July 2023
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Methicillin-resistant Staphylococcus Aureus (MRSA) bacteremia is a complex and lethal condition. We reported the clinical case of a 58-year-old woman who developed MRSA bacteremia after a 3-month hospitalization for trauma and sepsis. Delay in diagnosis of aortic and mitral endocarditis in the setting of new-onset regurgitations, as the application of suboptimal therapy with linezolid and vancomycin, led to widespread disease with embolic dissemination and development of septic infarctions. Clinicians must be aware of the necessity to consider as high risk of endocarditis new onset valvular regurgitations and of the evidence about the need for daptomycin in treating high-risk MRSA bacteremia.

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Citations

Tabah A, Laupland KB. Update on Staphylococcus aureus bacteremia. Curr Opin Crit Care 2022;28:495-504. DOI: https://doi.org/10.1097/MCC.0000000000000974
Lam JC, Stokes W. The Golden Grapes of Wrath - Staphylococcus aureus Bacteremia: A Clinical Review. Am J Med 2023;136:19-26. DOI: https://doi.org/10.1016/j.amjmed.2022.09.017
Mokadam NA, Stout KK, Verrier ED. Management of acute regurgitation in left-sided cardiac valves. Tex Heart Inst J 2011;38:9-19.
Vieira ML, Grinberg M, Pomerantzeff PM, et al. Repeated echocardiographic examinations of patients with suspected infective endocarditis. Heart 2004;90:1020-4. DOI: https://doi.org/10.1136/hrt.2003.025585
Kouijzer IJE, Fowler VG Jr, Ten Oever J. Redefining Staphylococcus aureus bacteremia: A structured approach guiding diagnostic and therapeutic management. J Infect 2023;86:9-13. DOI: https://doi.org/10.1016/j.jinf.2022.10.042
Stevens DL, Herr D, Lampiris H, et al. Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections. Clin Infect Dis 2002;34:1481-90. DOI: https://doi.org/10.1086/340353
Conly JM, Johnston BL. VISA, hetero-VISA and VRSA: the end of the vancomycin era? Can J Infect Dis 2002;13:282-4. DOI: https://doi.org/10.1155/2002/245109
Samura M, Kitahiro Y, Tashiro S, et al. Efficacy and Safety of Daptomycin versus Vancomycin for Bacteremia Caused by Methicillin-Resistant Staphylococcus aureus with Vancomycin Minimum Inhibitory Concentration >1 μg/mL: A Systematic Review and Meta-Analysis. Pharmaceutics 2022;14:714. DOI: https://doi.org/10.3390/pharmaceutics14040714
Habib G, Lancellotti P, Antunes MJ, et al. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J 2015;36:3075-128. DOI: https://doi.org/10.1093/eurheartj/ehv319
Feuchtner GM, Stolzmann P, Dichtl W, et al. Multislice computed tomography in infective endocarditis: comparison with transesophageal echocardiography and intraoperative findings. J Am Coll Cardiol 2009;53:436-44. DOI: https://doi.org/10.1016/j.jacc.2008.01.077

How to Cite

Cinquegrani, M., Cei, F., Pistoia, M., & Mumoli, N. (2023). MRSA bacteremia and new-onset aortic and mitral regurgitation: a pernicious and tricky association. Italian Journal of Medicine, 17(2). https://doi.org/10.4081/itjm.2023.1618