https://doi.org/10.4081/itjm.2022.1560

Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients

Vol. 16 No. 1 (2022)
Submitted: 5 December 2022
Accepted: 29 December 2022
Published: 30 December 2022
Ischemia modified albumin, hemodialysis, oxidative stress, chronic kidney disease, bone mineral disease, parathormone.
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Authors

Kenan Güçlü
https://orcid.org/0000-0002-0092-652X
Biochemistry Department, Kayseri State Hospital, Kayseri, Turkey.
Kağan Tur
kaantur542@gmail.com
https://orcid.org/0000-0001-5989-2099
Internal Medicine Department, Faculty of Medicine, Ahi Evran University, Kırşehir, Turkey.
Serdar Şahin
General Surgery Department, Faculty of Medicine, Ahi Evran University, Kırşehir, Turkey.
Aydın Güçlü
Nephrology Department, Faculty of Medicine, Ahi Evran University, Kırşehir, Turkey.

Hemodialysis patients are the group which oxidative stress is found more exacerbated. Ischemia modified albumin (IMA) is a new and sensitive marker for ischemia and oxidative stress. At current study we evaluated relation between IMA and biochemical parameters in hemodialysis patients. Thirty-four patients on maintenance hemodialysis were included. Prehemodialysis and post-hemodialysis blood samples were taken. Serum IMA and biochemistry parameters were measured. There was a positive correlation between alkaline phosphatase (ALP) and IMA (r=0.268, P<0.05), CRP and IMA (r=0.452, P=0.007), parathormone and IMA (r=0.436, P=0.010), There was a negative correlation between albumin and IMA (r= –0.338, P=0.05). Multiple regression analysis was run to predict IMA levels from parathormone, CRP and creatinine the model statistically significantly predicted relation P<0.05, R=0.506, out of four two variables added statistically significant to the prediction, PTH (P=0.006), CRP (P=0.029). In multiregression analysis, IMA was found to be associated with PTH and CRP independent of creatinine value. We showed for the first time that PTH is associated with IMA in hemodialysis patients, independent of the level of renal function.

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How to Cite

Güçlü, K., Tur, K., Şahin, S., & Güçlü, A. (2022). Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients. Italian Journal of Medicine, 16(1). https://doi.org/10.4081/itjm.2022.1560
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