https://doi.org/10.4081/itjm.2022.1550

Serum interleukin-6 is associated with hypocalcemia, hypoferritinemia and hyperkalemia in end-stage renal disease patients

Vol. 16 No. 1 (2022)
Submitted: 15 November 2022
Accepted: 30 December 2022
Published: 30 December 2022
Interleukin-6, minerals, hypocalcemia, hypoferritinemia, hyperkalemia, end stage renal failure.
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Authors

Ghassaq T. Alubaidi
ghasaqtariq119@gmail.com
https://orcid.org/0000-0002-7287-9398
Medical Research Unit, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
Yasameen A. Humadi
Internal Medicine Department, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
Dalyia A. Hamoodi
Natural Resources Engineering and Management, Kurdistan University, Erbil, Iraq.
Hasanain Tuama Mahdi
Hemodialysis Unit, Immamain Alkadhymain Medical City, Baghdad, Iraq.
Bushra Auid Anid
Hemodialysis Unit, Immamain Alkadhymain Medical City, Baghdad, Iraq.
Ilham Ahmed Jasim
Medical Research Unit, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
Ibrahim Mohammed Abdalfatah
Hemodialysis Unit, Immamain Alkadhymain Medical City, Baghdad, Iraq.

Both of chronic inflammation and mineral disturbance are major concerns in patients with chronic kidney disease, particularly end-stage renal disease (ESRD). The present study aimed to investigate the association between circulating interleukin-6 (IL-6) and minerals dysregulation in patients diagnosed with ESRD and on a continuous hemodialysis regimen. This cross-sectional study included 74 patients undergoing continuous hemodialysis. Serum samples were tested for IL-6 using an enzyme-linked immunosorbent assay. Mineral were analyzed using an electrolyte analyzer and biochemical tests. Parameter correlations were analyzed using the Pearson’s correlation test. Among the studies group, the male: female ratio was 1:0.72. IL-6 mean value was 13.77 pg/mL ±9.79 SD. IL-6 was significantly negatively correlated with circulating iron and calcium levels (r= –0.229, P=0.049; r= –0.252, P=0.03, respectively). IL-6 was significantly positively correlated with K+ levels (r=0.269, P=0.02). The present study highlighted the substantial role of IL-6 in mineral dysregulation in hemodialysis patients. However, identifying IL-6 as potential therapeutic target for minimizing and monitoring clinical effects of mineral disturbances in hemodialysis patients still requires further confirmatory studies.

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How to Cite

Alubaidi, G. T., Humadi , Y. A., Hamoodi, D. A., Mahdi , H. T., Anid, B. A., Jasim, I. A., & Abdalfatah, I. M. (2022). Serum interleukin-6 is associated with hypocalcemia, hypoferritinemia and hyperkalemia in end-stage renal disease patients. Italian Journal of Medicine, 16(1). https://doi.org/10.4081/itjm.2022.1550
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