Atypical presentation of West Nile encephalitis: a brief report and review of the current literature

Submitted: 25 September 2022
Accepted: 7 November 2022
Published: 30 December 2022
Abstract Views: 893
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Authors

West Nile virus (WNV) causes both sporadic and epidemic infections, which may be accompanied by severe neurologic involvement. The infection is transmitted to humans primarily through mosquito bites, and the virus is maintained through a cycle in which birds serve as its primary host. The typical involvement of the central nervous system is indistinguishable from other pathogens’ meningitis and encephalitis. In this report, we describe an atypical presentation of WNV meningoencephalitis in an 81-year-old female patient who initially displayed psychiatric symptoms. Anamnestic information was crucial for diagnosing the correct condition. Upon learning that the patient lived near a natural bird reserve, the search for the agent responsible for meningoencephalitis was directed.

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Citations

Smithburn K, Hughes T, Burke A, et al. A neurotropic virus isolated from the blood of a native of Uganda. Am J Trop Med 1940;20:471.
Petersen LR. Epidemiology of West Nile Virus in the United States: implications for arbovirology and public health. J Med Entomol 2019;56:1456-62.
Colpitts TM, Conway MJ, Montgomery RR, Fikrig E. West Nile Virus: biology, transmission, and human infection. Clin Microbiol Rev 2012;25:635-48.
Rizzo C, Salcuni P, Nicoletti L, et al. Epidemiological surveillance of West Nile neuroinvasive diseases in Italy, 2008 to 2011. Euro Surveill 2012;17:20172.
Tsai TF, Popovici F, Cernescu C, et al. West Nile encephalitis epidemic in southeastern Romania. Lancet 1998;352:767-71.
Conte A, Candeloro L, Ippoliti C, et al. Spatio-temporal identification of areas suitable for West Nile Disease in the Mediterranean Basin and Central Europe. PLoS One 2015;10:e0146024.
Tran A, Sudre B, Paz S, et al. Environmental predictors of West Nile fever risk in Europe. Int J Health Geogr 2014;13:26.
European Centre for Disease Prevention and Control (ECDC). West Nile fever maps. Accessed: 27 Sep 2012. Available from: http://ecdc.europa.eu/en/healthtopics/west_nile_fever/West-Nile-fever-maps/pages/index.aspx
Rizzo C, Vescio F, Declich S, et al. West Nile virus transmission with human cases in Italy, August-September 2009. Euro Surveill 2009;14:19353.
European Centre for Disease Prevention and Control (ECDC). Epidemiological situation of West Nile virus infection in the European Union; 13 July 2012. Available from: http://ecdc.europa.eu/en/publications/publications/1207-ter-rapid-risk-assessment-west-nile-virus.pdf
Rizzoli A, Jimenez-Clavero MA, Barzon L, et al. The challenge of West Nile virus in Europe: knowledge gaps and research priorities. Euro Surveill 2015;20:21135.
Bunning ML, Bowen RA, Cropp CB, et al. Experimental infection of horses with West Nile virus. Emerg Infect Dis 2002;8:380-6.
Autorino GL, Battisti A, Deubel V, et al. West Nile virus epidemic in horses, Tuscany region, Italy. Emerg Infect Dis 2002;8:1372-8.
Magurano F, Remoli ME, Baggieri M, et al. Circulation of West Nile virus lineage 1 and 2 during an outbreak in Italy. Clin Microbiol Infect 2012;18:E545-7.
Zou S, Foster GA, Dodd RY, et al. West Nile fever characteristics among viremic persons identified through blood donor screening. J Infect Dis 2010;202:1354-61.
Murray K, Walker C, Herrington E, et al. Persistent infection with West Nile virus years after initial infection. J Infect Dis 2010;201:2-4.
Sejvar JJ. Clinical manifestations and outcomes of West Nile virus infection. Viruses 2014;6:606-23.
Aronin SI, Peduzzi P, Quagliarello VJ. Community-acquired bacterial meningitis: risk stratification for adverse clinical outcome and effect of antibiotic timing. Ann Intern Med 1998;129:862-9.
Benson PC, Swadron SP. Empiric acyclovir is infrequently initiated in the emergency department to patients ultimately diagnosed with encephalitis. Ann Emerg Med 2006;47:100-5.
Tunkel AR, Hartman BJ, Kaplan SL, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004;39:1267-84.
Orton SL, Stramer SL, Dodd RY. Self-reported symptoms associated with West Nile virus infection in RNA-positive blood donors. Transfusion 2006;46:272-7.
Huhn GD, Dworkin MS. Rash as a prognostic factor in West Nile virus disease. Clin Infect Dis 2006;43:388-9.
Davis LE, DeBiasi R, Goade DE, et al. West Nile virus neuroinvasive disease. Ann Neurol 2006;60:286-300.
Sejvar JJ, Haddad MB, Tierney BC, et al. Neurologic manifestations and outcome of West Nile virus infection. JAMA 2003;290:511-5.
Sutinen J, Fell DB, Sander B, Kulkarni MA. Comorbid conditions as risk factors for West Nile neuroinvasive disease in Ontario, Canada: a population-based cohort study. Epidemiol Infect 2022;150:e103.
Charrel RN, Bichaud L, de Lamballerie X. Emergence of Toscana virus in the mediterranean area. World J Virol 2012;1:135-41.

How to Cite

Cioni, G., Fedeli, A., Bellandi, G., Squillante, R., Zuccotti, M., & Buffini, G. (2022). Atypical presentation of West Nile encephalitis: a brief report and review of the current literature. Italian Journal of Medicine, 16(1). https://doi.org/10.4081/itjm.2022.1535