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Antibiotic use in Departments of Internal Medicine of Lazio

Dario Martolini, Maurizia Galiè, Anna Maria Santoro, Danilo Monno, Claudio Santini, David Terracina, on behalf of FADOI Lazio - Area of Infectious Diseases
  • Dario Martolini
    Department of Internal Medicine, Madre Giuseppina Vannini Hospital, Figlie di San Camillo Institute, Roma, Italy | martolini.dario@yahoo.it
  • Maurizia Galiè
    Department of Internal Medicine, Madre Giuseppina Vannini Hospital, Figlie di San Camillo Institute, Roma, Italy
  • Anna Maria Santoro
    Department of Internal Medicine, Sandro Pertini Hospital, Roma, Italy
  • Danilo Monno
    Department of Internal Medicine, Fatebenefratelli Hospital, Isola Tiberina, Roma, Italy
  • Claudio Santini
    Department of Internal Medicine, Madre Giuseppina Vannini Hospital, Figlie di San Camillo Institute, Roma, Italy
  • David Terracina
    Department of Internal Medicine, Sandro Pertini Hospital, Roma, Italy
  • on behalf of FADOI Lazio - Area of Infectious Diseases
    Affiliation not present

Abstract

Antimicrobial therapy is inappropriate in 9 to 64% of the patients hospitalized. We evaluated the antibiotic use in Internal Medicine wards of an Italian region (Lazio) by a prospective multicenter, observational study. One thousand and nine patients were evaluated. Patients under antimicrobial treatment (PUAT) were 588 (58.2%), patients without treatment (PWT) 421 (41.8%). Infections were classified as community acquired (47.8%), hospital acquired (10.3%) or healthcare-associated (11.4%); the remaining 30.5% of infections did not receive any epidemiological classification. Samples for microbiological examination were collected in 41.6% of PUAT. The antibiotic choice was empiric in 94.8% of the cases and protected penicillins were selected in 48% of the cases. The mean duration of treatment was 9.5±6 standard deviation (SD) days. Only 6% of the patients switched from intravenous to oral therapy. Age, length of hospital stay and mortality were higher for PUAT than for PWT (mean age: 75.9±15 SD vs 74.2±15 SD years, P<0.02; length of hospital stay: 13.7±10.4 SD vs 10±8.4 SD days, P<0.01; mortality: 15.9% vs 3.1%). Antibiotic stewardship needs to be implemented all over the hospitals of Lazio region.

Keywords

Antibiotic consumption; antibiotic stewardship; infectious diseases.

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Submitted: 2016-12-02 15:08:21
Published: 2017-11-28 14:02:09
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Copyright (c) 2017 Dario Martolini, Maurizia Galiè, Anna Maria Santoro, Danilo Monno, Claudio Santini, David Terracina, on behalf of FADOI Lazio - Area of Infectious Diseases

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