Transient idiopathic central diabetes insipidus: is severe sepsis a possible cause?

Submitted: 26 March 2016
Accepted: 23 August 2016
Published: 15 March 2017
Abstract Views: 1552
PDF: 733
HTML: 1197
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Idiopathic central diabetes insipidus (CDI) is a disorder characterized by hypotonic polyuria and polydipsia, without any identified etiology. Here we report a case of a 57-year-old woman, with idiopathic CDI, admitted to our department with severe sepsis and acute kidney failure. After clinical and radiological investigations, she was diagnosed with idiopathic CDI. In this case report the findings suggest that severe sepsis could be the trigger for this disease. In addition, we hypothesise that apelin, a diuretic neuropeptide, plays a role in such a process. Apelin levels are known to increase during severe sepsis, which in turn counteracts vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

How to Cite

Lazzari, I., Graziani, A., Mirici, F., & Stefanini, G. F. (2017). Transient idiopathic central diabetes insipidus: is severe sepsis a possible cause?. Italian Journal of Medicine, 11(1), 78–81. https://doi.org/10.4081/itjm.2017.717

List of Cited By :

Crossref logo