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The impact of saffron (Crocus sativus) supplementation on visual function in patients with dry age-related macular degeneration

Abbas Riazi, Yunes Panahi, Ali A. Alishiri, Mohammad A. Hosseini, Ali A. Karimi Zarchi, Amirhossein Sahebkar
  • Abbas Riazi
    Department of Ophthalmology, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran, Islamic Republic of
  • Yunes Panahi
    Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Islamic Republic of | yunespanahi@yahoo.com
  • Ali A. Alishiri
    Department of Ophthalmology, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran, Islamic Republic of
  • Mohammad A. Hosseini
    Department of Ophthalmology, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran, Islamic Republic of
  • Ali A. Karimi Zarchi
    Department of Epidemiology and Biostatics, Baqiyatallah University of Medical Sciences, Tehran, Iran, Islamic Republic of
  • Amirhossein Sahebkar
    Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of

Abstract

The aim was to evaluate the impact of saffron supplementation on visual function in patients with dry age-related macular degeneration (ARMD). Fifty-four participants, 23 males and 31 females, with dry ARMD were assigned to one of the following two groups. The treatment group (n=29) consumed 50 mg saffron daily during a 3-month period, while 25 subjects served as the control group. Visual acuity, contrast sensitivity, and retinal thickness were measured at the beginning and at the end of the study. Quality of life was evaluated using the Melbourne low vision index before and after treatment. Significant increases in visual acuity and contrast sensitivity were found in the saffron group but not in the control group. Changes in macular thickness were not statistically different between the two groups. Short-term consumption of saffron may slow down the progression of disease and improve visual function, especially contrast sensitivity, in patients with dry ARMD.

Keywords

Saffron; age-related macular degeneration; visual acuity; contrast sensitivity; macular thickness.

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Submitted: 2016-07-02 16:10:38
Published: 2016-08-11 00:00:00
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Copyright (c) 2016 Abbas Riazi, Yunes Panahi, Ali A. Alishiri, Mohammad A. Hosseini, Ali A. Karimi Zarchi, Amirhossein Sahebkar

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