https://doi.org/10.4081/itjm.2017.719

The effect of the antioxidant drug U-74389G on urea levels during ischemia reperfusion injury in rats

Vol. 11 No. 3 (2017)
Submitted: 2 April 2016
Accepted: 15 April 2016
Published: 30 May 2017
Ischemia, U-74389G, urea, reperfusion.
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Authors

Constantinos Tsompos
Tsomposconstantinos@gmail.com
Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece.
Constantinos Panoulis
Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece.
Konstantinos Toutouzas
Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece.
Aggeliki Triantafyllou
Department of Biologic Chemistry, Athens University, Attiki, Greece.
George Zografos
Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece.
Apostolos Papalois
Experimental Research Centre, ELPEN Pharmaceuticals, S.A. Inc., Co., Athens, Greece.
This experimental study examined the effect of the antioxidant drug U-74389G, on a rat model and particularly in a renal ischemia- reperfusion protocol. The effects of that molecule were studied biochemically using blood mean urea levels. Forty rats of mean weight 231.875 g were used in the study. Urea levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D. U-74389G administration significantly decreased the predicted urea levels by 11.35%±2.73% (P=0.0001). Reperfusion time non-significantly increased the predicted urea levels by 2.26%±3.29% (P=0.4103). However, U-74389G administration and reperfusion time together significantly decreased the predicted urea levels by 6.31%±1.70% (P=0.0005). U-74389G administration whether it interacted or not with reperfusion time had significant decreasing effect on the urea serum levels, reflecting a respective renal function augmentation.

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Supporting Agencies

Acknowledgment, This study was funded by Scholarship by the Experimental Research Centre ELPEN Pharmaceuticals (E.R.C.E), Athens, Greece. The research facilities for this project were provided by the aforementioned institution.

How to Cite

Tsompos, C., Panoulis, C., Toutouzas, K., Triantafyllou, A., Zografos, G., & Papalois, A. (2017). The effect of the antioxidant drug U-74389G on urea levels during ischemia reperfusion injury in rats. Italian Journal of Medicine, 11(3), 305–309. https://doi.org/10.4081/itjm.2017.719

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