https://doi.org/10.4081/itjm.2017.717

Transient idiopathic central diabetes insipidus: is severe sepsis a possible cause?

Vol. 11 No. 1 (2017)
Submitted: 26 March 2016
Accepted: 23 August 2016
Published: 15 March 2017
Central diabetes insipidus, vasopressin, severe sepsis, apelin.
Abstract Views: 1604
PDF: 779
HTML: 1330
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Ilaria Lazzari
ilaria.lazzari17@gmail.com
Department of Internal Medicine, Sant'Orsola Hospital, Bologna, Italy.
Alessandro Graziani
Department of Internal Medicine, Faenza Hospital, Faenza (RA), Italy.
Federica Mirici
Department of Internal Medicine, Faenza Hospital, Faenza (RA), Italy.
Giuseppe Francesco Stefanini
Department of Internal Medicine, Faenza Hospital, Faenza (RA), Italy.
Idiopathic central diabetes insipidus (CDI) is a disorder characterized by hypotonic polyuria and polydipsia, without any identified etiology. Here we report a case of a 57-year-old woman, with idiopathic CDI, admitted to our department with severe sepsis and acute kidney failure. After clinical and radiological investigations, she was diagnosed with idiopathic CDI. In this case report the findings suggest that severe sepsis could be the trigger for this disease. In addition, we hypothesise that apelin, a diuretic neuropeptide, plays a role in such a process. Apelin levels are known to increase during severe sepsis, which in turn counteracts vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

PlumX Metrics

PlumX Metrics  provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Lazzari, I., Graziani, A., Mirici, F., & Stefanini, G. F. (2017). Transient idiopathic central diabetes insipidus: is severe sepsis a possible cause?. Italian Journal of Medicine, 11(1), 78–81. https://doi.org/10.4081/itjm.2017.717

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.